Centre of Bio-Medical Research, Sanjay Gandhi Postgraduate Institute of Medical Sciences Campus, Lucknow, Uttar Pradesh, 226014, India.
Department of Information Technology, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Brain Imaging Behav. 2022 Feb;16(1):22-30. doi: 10.1007/s11682-021-00473-0. Epub 2021 Apr 12.
Bipolar disorder (BPD) is a psychiatric condition driving frequent mood swings between periodic extremes of happiness and depression in patients. In this study, a source-based morphometry (SBM) and voxel-based morphometry (VBM) analysis was utilized to measure the differences in the white matter (WM) and grey matter (GM) between euthymic children with BPD and typically developing (TD) children. We adapted both multivariate (SBM) and univariate (VBM) analysis in 20 children with BPD euthymia /remission and compared to the same number of TD age-matched children. The VBM did not reveal any increase in GM and WM voxel values in children with BPD. However, a decrease in the GM voxel values in the bilateral middle frontal and WM voxels in the left hippocampus, left caudate, left orbitofrontal and right inferior parietal cortices was identified. Conversely, SBM analysis in BPD displayed a high GM value in bilateral angular gyrus, bilateral inferior temporal, left supplementary motor area and left middle temporal region, while a low value was observed in left inferior and middle occipital, cerebellum, thalamus, left premotor area and left lingual gyrus. These findings suggested a crucial GM and WM alteration in multiple neural regions in BPD children even during sustained and substantial remission.
双相情感障碍（BPD）是一种精神疾病，会导致患者的情绪在周期性的极度快乐和抑郁之间频繁波动。在这项研究中，我们采用基于体素的形态计量学（VBM）和基于体素的形态计量学（SBM）分析来测量缓解期双相情感障碍儿童与正常发育（TD）儿童之间的白质（WM）和灰质（GM）差异。我们分别对 20 名缓解期双相情感障碍儿童和相同数量的年龄匹配的 TD 儿童进行了多变量（SBM）和单变量（VBM）分析。VBM 未发现缓解期双相情感障碍儿童的 GM 和 WM 体素值增加。然而，在双侧额中回和左侧海马体、左侧尾状核、左侧眶额回和右侧顶下小叶的 GM 体素值降低。相反，BPD 的 SBM 分析显示双侧角回、双侧颞下回、左侧辅助运动区和左侧颞中回的 GM 值较高，而左侧枕中回和枕下回、小脑、丘脑、左侧运动前区和左侧舌回的 GM 值较低。这些发现表明，即使在持续和大量缓解期，BPD 儿童的多个神经区域的 GM 和 WM 也发生了重要改变。
