Division of Endocrinology, Diabetes & Metabolism, Tel Aviv University, Tel Aviv, Israel.
Endo-Oncology Clinic, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel.
Immunotherapy. 2021 Jun;13(8):653-659. doi: 10.2217/imt-2020-0332. Epub 2021 Apr 13.
Capillary-leak syndrome is strongly associated with cytokine activity states. It is an ill-recognized adverse effect of checkpoint inhibitors treatment, which are typically associated with cellular immune response. We describe two patients with capillary leak syndrome following immune checkpoint inhibitors treatment. We present linking mechanisms between checkpoint inhibitors, cellular immunity, cytokine action and endothelial damage. We suggest that capillary-leak syndrome is a unique adverse effect of immunotherapy, resulting from complex interactions between cellular and cytokine activation and that its expression is probably depending on inherent host immune variabilities.
毛细血管渗漏综合征与细胞因子活性状态密切相关。它是检查点抑制剂治疗的一种未被充分认识的不良反应，而检查点抑制剂通常与细胞免疫反应相关。我们描述了两例接受免疫检查点抑制剂治疗后出现毛细血管渗漏综合征的患者。我们提出了检查点抑制剂、细胞免疫、细胞因子作用和内皮损伤之间的联系机制。我们认为毛细血管渗漏综合征是免疫治疗的一种独特的不良反应，是细胞和细胞因子激活之间复杂相互作用的结果，其表达可能取决于固有宿主免疫的可变性。
