Gragnano Felice, Pasceri Vincenzo, Limongelli Giuseppe, Tanzilli Gaetano, Calabrò Paolo, Pelliccia Francesco
Cattedra di Cardiologia, Università della Campania "Luigi Vanvitelli", U.O.C. Cardiologia-UTIC, AORN Sant'Anna e San Sebastiano, Caserta.
U.O. Cardiologia, Dipartimento Cardiovascolare, Ospedale San Filippo Neri, Roma.
G Ital Cardiol (Rome). 2021 Mar;22(3 Suppl 1):25S-31S. doi: 10.1714/3578.35631.
Alcohol septal ablation is a minimally invasive, safe, and effective procedure for the treatment of left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite maximal medical therapy. Originally performed by Ulrich Sigwart in 1994, the procedure causes a iatrogenic infarction - through the injection of absolute alcohol - of the basal portion of the interventricular septum and aims at reducing LVOT obstruction in order to improve patient's hemodynamics and symptoms. Numerous studies have demonstrated the effectiveness and safety of the procedure, making it a valid alternative to surgical myectomy. The success of alcohol septal ablation depends upon the selection of the patient and the experience of both the operators and the center where the procedure is performed. In this review, we summarize current evidence on alcohol septal ablation, describe its procedural aspects and propose a multidisciplinary approach that involves a team of clinical cardiologists, interventionists, and cardiac surgeons, the Cardiomyopathy Team, with high experience in the clinical management of these patients.
酒精间隔消融术是一种微创、安全且有效的治疗方法,用于治疗肥厚性梗阻性心肌病(HOCM)患者的左心室流出道(LVOT)梗阻,这些患者尽管接受了最大程度的药物治疗仍有症状。该手术最初由乌尔里希·西格瓦特于1994年实施,通过注射无水酒精导致室间隔基部发生医源性梗死,旨在减轻LVOT梗阻,以改善患者的血流动力学和症状。大量研究已证明该手术的有效性和安全性,使其成为外科心肌切除术的有效替代方法。酒精间隔消融术的成功取决于患者的选择以及手术操作者和实施手术中心的经验。在本综述中,我们总结了关于酒精间隔消融术的当前证据,描述其手术方面,并提出一种多学科方法,该方法涉及一组临床心脏病专家、介入专家和心脏外科医生,即心肌病团队,他们在这些患者的临床管理方面经验丰富。