从假单胞菌属中分离出一种新的吩嗪抗生素DOB-41。

Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species.

作者信息

Shoji J, Sakazaki R, Nakai H, Terui Y, Hattori T, Shiratori O, Kondo E, Konishi T

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1988 May;41(5):589-94. doi: 10.7164/antibiotics.41.589.

DOI:10.7164/antibiotics.41.589

PMID:3384746

Abstract

A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C19H18N2O6, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.

摘要

一种新的吩嗪类抗生素DOB - 41从假单胞菌菌株的培养液中分离出来。所获得的呈黄色晶体状的抗生素在255纳米和370纳米处有紫外吸收最大值。通过元素分析和质谱分析确定其分子式为C19H18N2O6。通过X射线衍射分析阐明了其结构。该抗生素对革兰氏阳性菌具有抑制活性，对小鼠白血病P388具有抗肿瘤作用。