Alahmadi Adnan A S
Department of Diagnostic Radiology, College of Applied Medical Science, King Abdulaziz University , Jeddah, Saudi Arabia.
Insights Imaging. 2021 Apr 13;12(1):47. doi: 10.1186/s13244-021-00993-9.
Traditionally, the superior parietal lobule (SPL) is usually investigated as one region of interest, particularly in functional magnetic resonance imaging (fMRI) studies. However, cytoarchitectonic analysis has shown that the SPL has a complex, heterogeneous topology that comprises more than seven sub-regions. Since previous studies have shown how the SPL is significantly involved in different neurological functions-such as visuomotor, cognitive, sensory, higher order, working memory and attention-this study aims to investigate whether these cytoarchitecturally different sub-regions have different functional connectivity to different functional brain networks.
This study examined 198 healthy subjects using resting-state fMRI and investigated the functional connectivity of seven sub-regions of the SPL to eight regional functional networks.
The findings showed that most of the seven sub-regions were functionally connected to these targeted networks and that there are differences between these sub-regions and their functional connectivity patterns. The most consistent functional connectivity was observed with the visual and attention networks. There were also clear functional differences between Brodmann area (BA) 5 and BA7. BA5, with its three sub-regions, had strong functional connectivity to both the sensorimotor and salience networks.
These findings have enhanced our understanding of the functional organisations of the complexity of the SPL and its varied topology and also provide clear evidence of the functional patterns and involvements of the SPL in major brain functions.
传统上，上顶叶小叶（SPL）通常作为一个感兴趣的区域进行研究，尤其是在功能磁共振成像（fMRI）研究中。然而，细胞构筑学分析表明，SPL具有复杂的异质性拓扑结构，包含七个以上的亚区域。由于先前的研究已经表明SPL如何显著参与不同的神经功能，如视觉运动、认知、感觉、高阶、工作记忆和注意力，本研究旨在调查这些细胞构筑学上不同的亚区域是否与不同的功能性脑网络具有不同的功能连接。
本研究使用静息态fMRI检查了198名健康受试者，并研究了SPL的七个亚区域与八个区域性功能网络的功能连接。
研究结果表明，七个亚区域中的大多数在功能上与这些目标网络相连，并且这些亚区域及其功能连接模式之间存在差异。观察到与视觉和注意力网络的功能连接最为一致。布罗德曼区（BA）5和BA7之间也存在明显的功能差异。BA5及其三个亚区域与感觉运动和突显网络都有很强的功能连接。
这些发现加深了我们对SPL复杂性及其多样拓扑结构的功能组织的理解，也为SPL在主要脑功能中的功能模式和参与提供了明确证据。
