Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, California, USA.
Department of Population Science, City of Hope National Medical Center, Duarte, California, USA.
Brain Behav. 2024 Aug;14(8):e3634. doi: 10.1002/brb3.3634.
The purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long-term breast cancer survivors 5-15 years after chemotherapy treatment.
Older breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C-) 5-15 years prior and age- and sex-matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI.
The study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C+ group, 12 participants for the C- group, and 13 participants for the HC group. The C+ group had increased gyrification in six local gyral regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in two local gyral regions from TP1 to TP2 (p < .05, Bonferroni corrected). The C- and HC groups showed decreased gyrification only (p < .05, Bonferroni corrected). In the C+ group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated (R = -0.76, p = .01).
Altered gyrification could be the neural correlate of cognitive changes in older chemotherapy-treated long-term breast cancer survivors.
本前瞻性纵向研究旨在评估化疗治疗 5-15 年后老年长期乳腺癌幸存者脑表面脑回变化。
招募了年龄≥65 岁、接受化疗（C+）或未接受化疗（C-）5-15 年且年龄和性别匹配的健康对照者（HC）（时间点 1（TP1）），并进行了 2 年的随访（时间点 2（TP2））。两次时间点的研究评估均包括神经心理学（NP）测试，使用 NIH 工具包认知电池和皮质脑回分析基于脑 MRI。
具有 TP1 和 TP2 数据的研究队列包括以下人员：C+组 10 名参与者、C-组 12 名参与者和 HC 组 13 名参与者。C+组在六个局部脑回区域（包括右侧梭状回、旁中央回、楔前回、上颞回、中颞回和左侧额下回）的脑回增加，从 TP1 到 TP2 的两个局部脑回区域的脑回减少（p<0.05，Bonferroni 校正）。C-组和 HC 组仅显示脑回减少（p<0.05，Bonferroni 校正）。在 C+组中，右侧旁中央脑回变化与晶体综合评分呈负相关（R=-0.76，p=0.01）。
改变的脑回可能是老年化疗治疗长期乳腺癌幸存者认知变化的神经相关物。
