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机器人辅助腹膜后淋巴结清扫术(RPLND):视频病例报告。

Robot-assisted retroperitoneal lymphadenectomy (RPLND): video case report.

作者信息

Gomes Daniel C, Da Costa Walter H, Brazão Éder S, Vergamini Lucas B, Ricci Bruno V, Zequi Stênio C

机构信息

Núcleo de Urologia, AC Camargo Cancer Center, São Paulo, SP, Brasil.

出版信息

Int Braz J Urol. 2021 Jul-Aug;47(4):907. doi: 10.1590/S1677-5538.IBJU.2020.0828.

Abstract

INTRODUCTION AND OBJECTIVE

: Germ cell tumors account for 90 to 95% of all testicular tumors. Approximately one-half of these cases are seminomas, and the other half constitutes non-seminomatous germ cell tumors (NSGCTs). The standard of care for men with more advanced or disseminated NSGCTs (stage IIB or higher) is to administer chemotherapy. In general, any patient with one or more residual retroperitoneal lymph nodes larger than 1cm following chemotherapy should undergo RPLND (1, 2). Laparoscopic/robotic RPLND is a technique that may reduce morbidity compared to the classic procedure (3). AFP, HCG and LDH are important tumor markers that are helpful in diagnosis, staging and evaluation of response to the therapy, although recently publications suggest that neutrophil to lymphocyte ratio (NLR) could be used as an alternative marker (4, 5).

MATERIALS AND METHODS

: We present a case of a 27-year-old male with prior right orchiectomy for NSGCT and residual retroperitoneal mass of 3.9 x 2.3cm (pT1pN2M0S1 EC IIB-low risk IGCCCG). He underwent platin-based chemotherapy and was eligible for surgery. Robot-assisted RPLND was then proceeded.

RESULTS

: Console operative time of 90min, total blood loss of 60cc and hospital discharge within 24h. Pathology report showed a post-pubertal teratoma metastasis and absence of capsular extravasation in 3 lymph nodes dissected. The control CT-Scan showed a significant improvement in radiological pattern and the patient is still on follow-up until the date of this video publication.

CONCLUSIONS

: The capability for 3-D visualization and complex dissection of vascular structures makes the robotic platform a powerful ally. Although further studies are required, our initial experience suggests that the robotic RPLND is feasible and reproducible, and should be encouraged in centers with high cancer volume where the robotic platform is available.

摘要

引言与目的

生殖细胞肿瘤占所有睾丸肿瘤的90%至95%。其中约一半病例为精原细胞瘤,另一半为非精原细胞性生殖细胞肿瘤(NSGCTs)。对于病情更严重或已发生播散的NSGCTs(IIB期或更高分期)男性患者,标准治疗方法是进行化疗。一般来说,任何化疗后有一个或多个残留腹膜后淋巴结直径大于1cm的患者都应接受腹膜后淋巴结清扫术(RPLND)(1,2)。与传统手术相比,腹腔镜/机器人辅助RPLND技术可能会降低发病率(3)。甲胎蛋白(AFP)、人绒毛膜促性腺激素(HCG)和乳酸脱氢酶(LDH)是重要的肿瘤标志物,有助于诊断、分期及评估治疗反应,不过最近的一些出版物表明中性粒细胞与淋巴细胞比值(NLR)可作为替代标志物(4,5)。

材料与方法

我们报告一例27岁男性患者,此前因NSGCT接受了右侧睾丸切除术,残留一个3.9×2.3cm的腹膜后肿块(pT1pN2M0S1 EC IIB - 低风险,国际生殖细胞癌协作组分类)。他接受了以铂类为基础的化疗,且符合手术条件。随后进行了机器人辅助腹膜后淋巴结清扫术。

结果

控制台手术时间为90分钟,总失血量为60cc,术后24小时内出院。病理报告显示为青春期后畸胎瘤转移,在清扫的3个淋巴结中未发现包膜外渗。对照CT扫描显示放射学表现有显著改善,截至本视频发布之日,该患者仍在接受随访。

结论

三维可视化及对血管结构进行复杂解剖的能力使机器人平台成为有力的助手。尽管还需要进一步研究,但我们的初步经验表明,机器人辅助腹膜后淋巴结清扫术是可行且可重复的,在有机器人平台且癌症病例量大的中心应鼓励开展此项手术。

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