Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Cancer Cell. 2021 Apr 12;39(4):463-465. doi: 10.1016/j.ccell.2021.03.005.
Using sophisticated statistical analyses on population-scale cancer whole-genome sequences, a new study published in Cell characterizes the genomic architecture of intratumor heterogeneity (ITH). It results in an unprecedented snapshot of subclones in about 30 cancer types, generating a wealth of insight into the underlying mutational events, processes, and their selection.
利用人口规模癌症全基因组序列的复杂统计分析，发表在《细胞》杂志上的一项新研究描绘了肿瘤内异质性（ITH）的基因组结构。该研究结果前所未有地描绘了大约 30 种癌症类型中的亚克隆，深入了解了潜在的突变事件、过程及其选择。
