CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, People's Republic of China.
J Chromatogr A. 2021 May 24;1645:462074. doi: 10.1016/j.chroma.2021.462074. Epub 2021 Mar 21.
We prepared two-dimensional (2D) bimetallic metal-organic frameworks (Ni-ZIF-8) nanosheets by a simple solvent-free method at room temperature. The morphology and composition of Ni-ZIF-8 can be controlled through adding different amounts of Ni. And then, the 2D magnetic mesoporous nanosheets (Ni/ZnO@C) were synthesized by directly pyrolyzing Ni-ZIF-8 under argon atmosphere and explored as magnetic solid phase extraction (MSPE) adsorbents for the determination of nitroimidazole antibiotics (NIABs). Magnetic Ni nanoparticles embedded in carbon nanosheets uniformly resulted in high magnetization saturation of Ni/ZnO@C for easy separation. The Ni/ZnO@C can form hydrogen bond and π-π interaction with three NIABs resulting from their rich N-H containing imidazole, π-electron. Due to the high specific surface area and high mass transfer rate of 2D Ni/ZnO@C, the materials showed satisfactory adsorption capacity and rapid adsorption kinetics for NIABs. A rapid and effective method of Ni/ZnO@C-MSPE combined with high-performance liquid chromatography was proposed for the determination of NIABs. Several main parameters affecting MSPE were investigated. Under the optimal conditions, wide linear was achieved ranging from 0.1 to 500 µg⋅L with a low detection limit of 0.025-0.05 µg⋅L. The established method has been successfully applied to analyze NIABs from environmental water samples with satisfactory recovery from 74.33 to 105.71%.
我们通过一种简单的室温无溶剂法制备了二维（2D）双金属金属有机骨架（Ni-ZIF-8）纳米片。通过添加不同量的 Ni，可以控制 Ni-ZIF-8 的形貌和组成。然后，通过在氩气气氛下直接热解 Ni-ZIF-8，合成了 2D 磁性介孔纳米片（Ni/ZnO@C），并将其作为磁性固相萃取（MSPE）吸附剂用于测定硝基咪唑类抗生素（NIABs）。嵌入在碳纳米片中的磁性 Ni 纳米颗粒导致 Ni/ZnO@C 具有高的饱和磁化强度，便于分离。Ni/ZnO@C 可以与三种 NIABs 形成氢键和π-π相互作用，这是由于它们富含 N-H 含有的咪唑和π电子。由于 2D Ni/ZnO@C 的比表面积高和传质速率高，该材料对 NIABs 表现出令人满意的吸附容量和快速的吸附动力学。提出了一种快速有效的 Ni/ZnO@C-MSPE 结合高效液相色谱法用于测定 NIABs。研究了影响 MSPE 的几个主要参数。在最佳条件下，线性范围从 0.1 到 500 µg⋅L，检测限低至 0.025-0.05 µg⋅L。该方法已成功应用于环境水样中 NIABs 的分析，回收率从 74.33%到 105.71%。
