Cárdenas A, Abián J, Bulbena O, Roselló J, Gelpi E
Department of Neurochemistry, Centro de Investigación y Desarrollo (CSIC), Barcelona, Spain.
J Chromatogr. 1988 Apr 8;426(1):83-91. doi: 10.1016/s0378-4347(00)81929-5.
The early identification of fatty acid anilides in suspect oils directed attention to their possible role in the Spanish toxic oil syndrome. These anilides or their oxidized derivatives could have been spontaneously formed during the handling and/or storage of the oil. The exact cause of the intoxication is still unknown but free radical and peroxidative mechanisms have been implicated in its etiology. Epoxy-hydroxylated derivatives from linoleic acid anilide were obtained using a model of accelerated oxidation. Their mass spectral patterns agree with the trimethylsilyl ethers of N-phenyl-9,10-epoxy-11-hydroxy-12-octadecenamide and N-phenyl-12,13-epoxy-11-hydroxy-9-octadecenamide, respectively. These compounds were also identified is rapeseed oil samples supplemented with N-phenyl-linoleamide and submitted to the reported accelerated oxidation method.
在可疑油类中脂肪酸苯胺类化合物的早期鉴定，使人们关注到它们在西班牙有毒油综合征中可能发挥的作用。这些苯胺类化合物或其氧化衍生物可能是在油的处理和/或储存过程中自发形成的。中毒的确切原因仍然未知，但自由基和过氧化机制被认为与其病因有关。使用加速氧化模型获得了亚油酸苯胺的环氧羟基化衍生物。它们的质谱图分别与N-苯基-9,10-环氧-11-羟基-12-十八碳烯酰胺和N-苯基-12,13-环氧-11-羟基-9-十八碳烯酰胺的三甲基硅醚一致。在添加了N-苯基-亚油酰胺并采用所报道的加速氧化方法的菜籽油样品中也鉴定出了这些化合物。
