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早期精神分裂症患者对自我和他人的消极与积极图式的神经元特征

Neuronal Signatures of Negative and Positive Schemas towards the Self and Others in Patients with Early Stage Schizophrenia.

作者信息

Shen Jie, Shen Guangfan, Kim Woo-Sung, Tsogt Uyanga, Liu Congcong, Sui Jing, Chung Young-Chul

机构信息

Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Republic of Korea.

Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

出版信息

Psychiatry Investig. 2021 Apr;18(4):284-294. doi: 10.30773/pi.2020.0335. Epub 2021 Apr 15.

DOI:10.30773/pi.2020.0335
PMID:33849245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8103021/
Abstract

OBJECTIVE

The present study investigated the functional neuroanatomy underlying negative and positive schemas towards the self and others in patients with early stage schizophrenia spectrum disorders (SSDs) using a task-based fMRI procedure.

METHODS

This study included 50 patients with SSDs and 52 controls. The schema-evoking task consisted of four active conditions and neutral condition. Differences in brain activation were compared between the two groups. Correlation analysis was performed between task-related activation and psychopathology.

RESULTS

The SSD patients exhibited higher activity of the left middle and inferior frontal gyri under the negative-others minus neutral contrast as well as greater activation of the left superior and middle frontal gyri and right medial superior frontal gyrus under the positive- self minus neutral and positive-others minus neutral contrasts. Under the positive-others minus neutral contrast, negative correlation was observed between activity of the right inferior parietal gyrus and right angular and total score of the Positive and Negative Syndrome Scale (PANSS), whereas positive correlation between activity of the left middle cingulate gyrus and left/right precuneus and positive-others score of the Brief Core Schema Scales (BCSS).

CONCLUSION

The present findings suggest that the frontal brain regions of SSD patients are more sensitive to negative and positive schemas towards the self and/or others compared to those of controls.

摘要

目的

本研究采用基于任务的功能磁共振成像（fMRI）程序，调查早期精神分裂症谱系障碍（SSDs）患者对自我和他人的消极和积极图式背后的功能神经解剖学。

方法

本研究纳入50例SSDs患者和52名对照者。图式诱发任务包括四种活跃状态和一种中性状态。比较两组之间的脑激活差异。对任务相关激活与精神病理学之间进行相关性分析。

结果

在消极-他人减去中性对比下，SSDs患者左侧额中回和额下回表现出更高的活性，在积极-自我减去中性和积极-他人减去中性对比下，左侧额上回和额中回以及右侧额内侧上回表现出更大的激活。在积极-他人减去中性对比下，观察到右侧顶下小叶和右侧角回的活性与阳性和阴性症状量表（PANSS）总分呈负相关，而左侧扣带中部回和左侧/右侧楔前叶的活性与简要核心图式量表（BCSS）的积极-他人得分呈正相关。

结论

目前的研究结果表明，与对照者相比，SSDs患者的额叶脑区对自我和/或他人的消极和积极图式更敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/625ef2cae118/pi-2020-0335f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/2817b02e780e/pi-2020-0335f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/eade30c84ef4/pi-2020-0335f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/32de28022c13/pi-2020-0335f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/625ef2cae118/pi-2020-0335f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/2817b02e780e/pi-2020-0335f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/eade30c84ef4/pi-2020-0335f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/32de28022c13/pi-2020-0335f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a843/8103021/625ef2cae118/pi-2020-0335f4.jpg

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