Cell Biology Program, Hospital for Sick Children, 686 Bay Street PGCRL, Toronto, ON, M5G 0A4, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A1, Canada.
BMC Biol. 2021 Apr 13;19(1):71. doi: 10.1186/s12915-021-00972-y.
Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience plasma membrane damage from a multitude of stressors in the extra- and intra-cellular environment. To avoid lethal consequences, cells are equipped with repair pathways to restore membrane integrity. Here, we assess plasma membrane damage and repair from a whole-body perspective. We highlight the role of tissue-specific stressors in health and disease and examine membrane repair pathways across diverse cell types. Furthermore, we outline the impact of genetic and environmental factors on plasma membrane integrity and how these contribute to disease pathogenesis in different tissues.
细胞膜完整性对于细胞内稳态至关重要。在体内，细胞会受到细胞内外环境中多种应激源的破坏。为了避免致命后果，细胞配备了修复途径来恢复膜的完整性。在这里，我们从整体的角度评估细胞膜的损伤和修复。我们强调了组织特异性应激源在健康和疾病中的作用，并研究了不同细胞类型的膜修复途径。此外，我们概述了遗传和环境因素对细胞膜完整性的影响，以及它们如何导致不同组织的疾病发病机制。
