Lang J, Price A B, Levi A J, Burke M, Gumpel J M, Bjarnason I
Department of Histopathology, Northwick Park Hospital, Harrow, Middlesex.
J Clin Pathol. 1988 May;41(5):516-26. doi: 10.1136/jcp.41.5.516.
Operative small bowel resection specimens received over a period of 16 years were reviewed to assess whether any intestinal disease could be directly attributed to the use of non-steroidal anti-inflammatory drugs (NSAID). Seven cases of intestinal disease associated with the use of NSAID were identified, all of which occurred in the final six years of the survey, which may reflect the increasing use of these compounds. A spectrum of patterns was found from multiple pathognomonic ileal mucosal diaphragms to broad strictures similar to those seen as a complication of enteric potassium. It seems likely that the formation of diaphragm lesions requires an additional factor, but what is not known as yet is whether the effects of NSAID are local or systemic.
对16年间接收的手术切除小肠标本进行回顾，以评估是否有任何肠道疾病可直接归因于非甾体抗炎药（NSAID）的使用。确定了7例与NSAID使用相关的肠道疾病病例，所有病例均发生在调查的最后6年，这可能反映了这些化合物使用的增加。发现了一系列病变模式，从多个具有病理特征的回肠黏膜隔膜到类似于肠道钾并发症所见的广泛狭窄。隔膜病变的形成似乎需要一个额外因素，但目前尚不清楚NSAID的作用是局部性还是全身性的。
