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1
Improved tumour localisation using indium-111 labelled antibodies.使用铟 - 111标记抗体改善肿瘤定位。
Br Med J (Clin Res Ed). 1983 Jul 16;287(6386):167-70. doi: 10.1136/bmj.287.6386.167.
2
Diverse characteristics of 111In labelled anti-CEA monoclonal antibodies for tumour immunoscintigraphy: radiolabelling, biodistribution and imaging studies in mice with human tumour xenografts.用于肿瘤免疫闪烁显像的铟-111标记抗癌胚抗原单克隆抗体的多样特性：放射性标记、生物分布及人肿瘤异种移植小鼠的成像研究
Eur J Nucl Med. 1987;12(10):515-21. doi: 10.1007/BF00620477.
3
Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. II. Biodistribution studies in mice with human tumour xenografts.碘和铟标记单克隆抗体在肿瘤组织与正常组织中的浓度差异。II. 人肿瘤异种移植小鼠的生物分布研究。
Eur J Nucl Med. 1985;11(8):300-4. doi: 10.1007/BF00252341.
4
A comparison of iodine and indium labelled anti CEA intact antibody, F(ab)2 and Fab fragments by imaging tumour xenografts.通过对肿瘤异种移植进行成像，比较碘和铟标记的抗癌胚抗原完整抗体、F(ab)2和Fab片段。
Eur J Nucl Med. 1988;13(11):598-604. doi: 10.1007/BF02574776.
5
Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. I. The effect on image contrast in clinical studies.碘和铟标记单克隆抗体在肿瘤组织与正常组织中的浓度差异。I. 对临床研究中图像对比度的影响。
Eur J Nucl Med. 1985;11(8):295-9. doi: 10.1007/BF00252340.
6
Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen.注射放射性标记的抗癌胚抗原后通过外部扫描对肿瘤沉积物进行定位。
Br Med J. 1980 Jan 26;280(6209):220-2. doi: 10.1136/bmj.280.6209.220.
7
Comparison of the distribution and binding of monoclonal antibodies labeled with 131-iodine or 111-indium.
Eur J Nucl Med. 1985;10(9-10):398-402. doi: 10.1007/BF00256578.
8
High-specific-activity 111In-labeled anticarcinoembryonic antigen monoclonal antibody: biodistribution and imaging in nude mice bearing human colon cancer xenografts.高比活度111铟标记的抗癌胚抗原单克隆抗体：在荷人结肠癌异种移植瘤裸鼠体内的生物分布及显像
Cancer Res. 1985 Nov;45(11 Pt 2):5700-6.
9
Dosimetric evaluation and radioimmunotherapy of anti-tumour multivalent Fab' fragments.抗肿瘤多价Fab'片段的剂量学评估与放射免疫治疗
Br J Cancer. 1999 Nov;81(6):972-80. doi: 10.1038/sj.bjc.6690795.
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Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.术前结直肠癌患者中铟 - 111标记的抗癌胚抗原嵌合单克隆抗体（嵌合T84.66）的剂量递增试验。
J Nucl Med. 1998 Dec;39(12):2097-104.

引用本文的文献

1
Development of Antibody Immuno-PET/SPECT Radiopharmaceuticals for Imaging of Oncological Disorders-An Update.用于肿瘤疾病成像的抗体免疫正电子发射断层显像/单光子发射计算机断层显像放射性药物的进展——最新情况
Cancers (Basel). 2020 Jul 11;12(7):1868. doi: 10.3390/cancers12071868.
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Imaging of recurrent intestinal carcinoma with indium-111-labeled anti-carcinoembryonic antigen monoclonal antibody CEA102.用铟-111标记的抗癌胚抗原单克隆抗体CEA102对复发性肠癌进行成像。
Jpn J Cancer Res. 1997 Jun;88(6):605-13. doi: 10.1111/j.1349-7006.1997.tb00425.x.
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Scanning for tumours with radiolabelled antibodies: a review.用放射性标记抗体扫描肿瘤：综述
J R Soc Med. 1983 Nov;76(11):957-60. doi: 10.1177/014107688307601113.
4
Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. II. Biodistribution studies in mice with human tumour xenografts.碘和铟标记单克隆抗体在肿瘤组织与正常组织中的浓度差异。II. 人肿瘤异种移植小鼠的生物分布研究。
Eur J Nucl Med. 1985;11(8):300-4. doi: 10.1007/BF00252341.
5
Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. I. The effect on image contrast in clinical studies.碘和铟标记单克隆抗体在肿瘤组织与正常组织中的浓度差异。I. 对临床研究中图像对比度的影响。
Eur J Nucl Med. 1985;11(8):295-9. doi: 10.1007/BF00252340.
6
Radionuclide imaging of ovarian tumours with a radiolabelled (123I) monoclonal antibody (NDOG2).用放射性标记的（123I）单克隆抗体（NDOG2）对卵巢肿瘤进行放射性核素成像。
Eur J Nucl Med. 1985;11(1):22-8. doi: 10.1007/BF00440956.
7
Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.用131I标记的癌胚抗原单克隆抗体对胃肠道癌进行定位
Br J Cancer. 1986 Feb;53(2):203-10. doi: 10.1038/bjc.1986.36.
8
The preparation and characterisation of 111In-labelled 791T/36 monoclonal antibody for tumour immunoscintigraphy.用于肿瘤免疫闪烁显像的¹¹¹铟标记791T/36单克隆抗体的制备与表征
Eur J Nucl Med. 1985;10(7-8):296-301. doi: 10.1007/BF00251299.
9
The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.人绒毛膜促性腺激素抗体成像在检测绒毛膜癌残留灶中的临床价值。
Br J Cancer. 1987 Jun;55(6):657-60. doi: 10.1038/bjc.1987.134.
10
Antibody-mediated targeting in the treatment and diagnosis of cancer: an overview.抗体介导的靶向作用在癌症治疗与诊断中的概述
Cancer Chemother Pharmacol. 1986;17(3):197-208. doi: 10.1007/BF00256685.

本文引用的文献

1
Radiolabeling of antibodies.抗体的放射性标记
Cancer Res. 1980 Aug;40(8 Pt 2):3036-42.
2
Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111-diethylenetriamine pentaacetic acid.用铟-111-二乙三胺五乙酸标记的抗犬心肌肌球蛋白抗体进行心肌梗死显像。
Science. 1980 Jul 11;209(4453):295-7. doi: 10.1126/science.7384803.
3
Theoretical limitations in the immunodiagnostic imaging of cancer with computed tomography and nuclear scanning.计算机断层扫描和核扫描在癌症免疫诊断成像中的理论局限性。
Cancer Res. 1980 Aug;40(8 Pt 2):3054-8.
4
Detection of thyroid tumours using radio-labelled anti-thyroglobulin.使用放射性标记的抗甲状腺球蛋白检测甲状腺肿瘤。
Clin Endocrinol (Oxf). 1983 Jun;18(6):563-70. doi: 10.1111/j.1365-2265.1983.tb00594.x.
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A shielded, sterile apparatus for iodinating proteins.
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6
Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases.人绒毛膜促性腺激素放射抗体在癌症的放射免疫检测及隐匿性转移灶的发现中的应用。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7754-8. doi: 10.1073/pnas.78.12.7754.
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Localisation of malignant germ-cell tumours by external scanning after injection of radiolabelled anti-alpha-fetoprotein.
Br Med J (Clin Res Ed). 1981 Oct 10;283(6297):942-4. doi: 10.1136/bmj.283.6297.942.
8
Targeting of iodine-123-labelled tumour-associated monoclonal antibodies to ovarian, breast, and gastrointestinal tumours.将碘-123标记的肿瘤相关单克隆抗体靶向卵巢、乳腺和胃肠道肿瘤。
Lancet. 1982 Nov 6;2(8306):999-1005. doi: 10.1016/s0140-6736(82)90046-0.
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Monoclonal antibodies for in-vivo localization.
Lancet. 1982 Sep 18;2(8299):660. doi: 10.1016/s0140-6736(82)92760-x.
10
Radioimmune assay of carcinoembryonic antigen.癌胚抗原的放射免疫测定
Immunochemistry. 1972 Mar;9(3):289-99. doi: 10.1016/0019-2791(72)90093-6.

使用铟 - 111标记抗体改善肿瘤定位。

Improved tumour localisation using indium-111 labelled antibodies.

作者信息

Fairweather D S, Bradwell A R, Dykes P W, Vaughan A T, Watson-James S F, Chandler S

出版信息

Br Med J (Clin Res Ed). 1983 Jul 16;287(6386):167-70. doi: 10.1136/bmj.287.6386.167.

DOI:10.1136/bmj.287.6386.167
PMID:6409238
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1548673/
Abstract

Immunoglobulin G (IgG) antibodies to carcinoembryonic antigen (CEA) were labelled with radioactive indium (111In) or iodine (131I) and a comparison made of their value in locating CEA producing tumours. Eleven patients given 111In-anti-CEA had 31 tumours as judged by a combination of all techniques. Of these, 28 were detected by 111In-anti-CEA and 26 by conventional clinical techniques. Five of the patients also received 131I-anti-CEA. These patients had 15 tumour areas. Thirteen were detected by 111In and eight by 131I. 111In also produced a better signal to noise ratio in the scans and thereby showed lesions with greater certainty. In addition, the 111In isotope continued to accumulate in the tumour areas for considerably longer than 131I. Absorbed doses (whole body) were similar for both isotopes. The results show that antibody scanning is greatly improved by using 111In as the radiolabel in place of 131I and should allow the detection of smaller or deeper lesions.

摘要

用放射性铟（111In）或碘（131I）标记癌胚抗原（CEA）的免疫球蛋白G（IgG）抗体，并比较它们在定位产生CEA的肿瘤中的价值。通过所有技术综合判断，11名接受111In - 抗CEA治疗的患者有31个肿瘤。其中，28个由111In - 抗CEA检测到，26个由传统临床技术检测到。5名患者还接受了131I - 抗CEA治疗。这些患者有15个肿瘤区域。13个由111In检测到，8个由131I检测到。111In在扫描中还产生了更好的信噪比，从而更确定地显示病变。此外，111In同位素在肿瘤区域的积累持续时间比131I长得多。两种同位素的全身吸收剂量相似。结果表明，用111In代替131I作为放射性标记可大大改善抗体扫描，并且应该能够检测到更小或更深的病变。