辅酶Q10缺乏导致癫痫患者癫痫发作的持续时间和频率增加。
Coenzyme Q10 Insufficiency Contributes to the Duration and Frequency of Seizures in Epileptic Patients.
作者信息
Simani Leila, Rezaei Omidvar, Ryan Fari, Sadeghi Masoumeh, Hooshmandi Etrat, Ramezani Mahtab, Pakdaman Hossin
机构信息
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Basic Clin Neurosci. 2020 Nov-Dec;11(6):765-771. doi: 10.32598/bcn.11.6.1100.1. Epub 2020 Nov 1.
INTRODUCTION
Oxidative stress has recently emerged as a possible mechanism in the pathogenesis of epilepsy. Coenzyme Q10 (CoQ10) is a strong endogenous antioxidant that protects cells from lipid oxidation and Reactive Oxygen Species (ROS) production; however, the impact of CoQ10 on seizure characteristics in epileptic patients is unclear.
METHODS
The current study enrolled patients with Epileptic Seizure (ES) to evaluate their serum concentration of CoQ10 and to investigate whether a relationship exists between CoQ10 levels with the duration, frequency, and type of seizure.
RESULTS
A total of 39 patients with epileptic seizures and 35 healthy controls were included in the study. The levels of CoQ10 in ES patients were significantly lower in comparison with healthy controls (11.99±5.93 vs (ng/ml). 16.48±4.20 (ng/ml) P<0.001). We also found that the duration of epilepsy and seizure frequency was negatively correlated with serum CoQ10 levels.
CONCLUSION
These findings indicate that CoQ10 deficiency might substantially contribute to the clinical signs of epileptic patients.
引言
氧化应激最近已成为癫痫发病机制中的一种可能机制。辅酶Q10（CoQ10）是一种强大的内源性抗氧化剂，可保护细胞免受脂质氧化和活性氧（ROS）生成的影响；然而，CoQ10对癫痫患者发作特征的影响尚不清楚。
方法
本研究纳入癫痫发作（ES）患者，以评估其血清CoQ10浓度，并调查CoQ10水平与发作持续时间、频率和类型之间是否存在关系。
结果
本研究共纳入39例癫痫发作患者和35例健康对照。与健康对照相比，ES患者的CoQ10水平显著降低（11.99±5.93 vs（纳克/毫升）。16.48±4.20（纳克/毫升）P<0.001）。我们还发现癫痫持续时间和发作频率与血清CoQ10水平呈负相关。
结论
这些发现表明，CoQ10缺乏可能在很大程度上导致癫痫患者的临床症状。
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