Alahmar Ahmed T, Singh Rajender
Department of Medical Physiology, College of Medicine, University of Babylon, Hillah, Iraq.
CSIR-Central Drug Research Institute, Lucknow, India.
Clin Exp Reprod Med. 2022 Mar;49(1):49-56. doi: 10.5653/cerm.2021.04910. Epub 2022 Feb 24.
Oxidative stress and sperm DNA fragmentation (SDF) have been linked to idiopathic male infertility (IMI). Various antioxidants have been tried to improve semen parameters and fertility potential in IMI patients, but with inconsistent results. The study aimed to compare the effects of coenzyme Q10 (CoQ10) and Centrum multivitamins on semen parameters, seminal antioxidant capacity, and SDF in infertile men with idiopathic oligoasthenospermia (OA).
This prospective controlled clinical study involved 130 patients with idiopathic OA and 58 fertile controls. The patients were divided randomly into two groups: the first group received CoQ10 (200 mg/day orally) and the second group received Centrum multivitamins (1 tablet/day) for 3 months. Semen parameters, CoQ10 levels, reactive oxygen species (ROS), total antioxidant capacity (TAC), catalase, SDF, and serum hormone levels (follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin) were compared at baseline and after 3 months.
Both CoQ10 and Centrum improved sperm concentration and motility, but the improvement was greater with Centrum therapy (p<0.05). Similarly, both therapies improved antioxidant capacity, but TAC and catalase improvement was greater (p<0.01 and p<0.001 respectively) with CoQ10, whereas ROS (p<0.01) and SDF (p<0.001) improvements were greater with Centrum administration. Centrum therapy was associated with reduced serum testosterone (p<0.05).
In conclusion, both CoQ10 and Centrum were effective in improving semen parameters, antioxidant capacity, and SDF, but the improvement was greater with Centrum than with CoQ10. Therefore, Centrum-as a source of combined antioxidants-may provide more effective results than individual antioxidants such as CoQ10 in the treatment of infertile men with idiopathic OA.
氧化应激和精子DNA碎片化（SDF）与特发性男性不育症（IMI）有关。人们尝试了各种抗氧化剂来改善IMI患者的精液参数和生育潜力，但结果并不一致。本研究旨在比较辅酶Q10（CoQ10）和善存多种维生素对特发性少弱精子症（OA）不育男性精液参数、精液抗氧化能力和SDF的影响。
这项前瞻性对照临床研究纳入了130例特发性OA患者和58例生育力正常的对照者。患者被随机分为两组：第一组口服CoQ10（200毫克/天），第二组每天服用1片善存多种维生素，为期3个月。在基线和3个月后比较精液参数、CoQ10水平、活性氧（ROS）、总抗氧化能力（TAC）、过氧化氢酶、SDF和血清激素水平（促卵泡激素、促黄体生成素、睾酮和催乳素）。
CoQ10和善存多种维生素均能改善精子浓度和活力，但善存多种维生素治疗的改善效果更显著（p<0.05）。同样，两种疗法均能提高抗氧化能力，但CoQ10治疗使TAC和过氧化氢酶的改善更显著（分别为p<0.01和p<0.001），而善存多种维生素给药使ROS（p<0.01）和SDF（p<0.001）的改善更显著。善存多种维生素治疗与血清睾酮降低有关（p<0.05）。
总之，CoQ10和善存多种维生素在改善精液参数、抗氧化能力和SDF方面均有效，但善存多种维生素的改善效果优于CoQ10。因此，作为复合抗氧化剂来源的善存多种维生素在治疗特发性OA不育男性方面可能比CoQ10等单一抗氧化剂提供更有效的结果。
