Miletto G, Merlihot J M, Nezri M, Stanoyevitch J F, Pernet-Rambaud C, Houis B
Service de Neurologie, CHG d'Aix-en Provence.
J Fr Ophtalmol. 1988;11(1):67-73.
19 patients with clinically definite, probable or possible multiple sclerosis were examined by means of visual evoked potentials and magnetic resonance imaging. The patients were classified in three groups according to the criteria of Mac Alpine. 11 patients had definite multiple sclerosis: 8 of these patients, who had visual disorders evoking an optic neuropathy, had abnormal visual evoked potentials and 7 of these 8 patients had a pathological magnetic resonance imaging. In the other 3 patients of this group without optic neuropathy. 2 of them had abnormal visual evoked potentials and the 3 had a pathological magnetic resonance imaging. Two patients had probable multiple sclerosis, one of them had abnormal visual evoked potentials and a pathological magnetic resonance imaging. Finally, 6 patients had possible multiple sclerosis, one had a optical neuropathy, with abnormal visual evoked potentials but with a normal magnetic resonance imaging. Among the 5 other patients, 2 had abnormal visual evoked potentials and a pathological magnetic resonance imaging. The results obtained in comparison with the other reported in the literature show that magnetic resonance imaging brings a certain number of criteria which when associated with visual evoked potentials seem to be a further development in the diagnosis of the affection. However, despite of the existence of correlations, the lack of specificity of the lesions found with magnetic resonance imaging should lead the clinicians to a cautions optimism.
对19例临床确诊、可能或疑似多发性硬化症的患者进行了视觉诱发电位和磁共振成像检查。根据麦克阿尔平标准，将患者分为三组。11例患者确诊为多发性硬化症：其中8例有视觉障碍引发视神经病变，视觉诱发电位异常，这8例中的7例磁共振成像检查结果异常。该组另外3例无视神经病变的患者中，2例视觉诱发电位异常，3例磁共振成像检查结果异常。2例患者可能患有多发性硬化症，其中1例视觉诱发电位异常且磁共振成像检查结果异常。最后，6例患者疑似患有多发性硬化症，1例有视神经病变，视觉诱发电位异常但磁共振成像检查结果正常。在其他5例患者中，2例视觉诱发电位异常且磁共振成像检查结果异常。与文献中其他报道结果相比，本研究结果表明，磁共振成像提供了一定数量的标准，与视觉诱发电位相结合似乎是该疾病诊断的进一步发展。然而，尽管存在相关性，但磁共振成像发现的病变缺乏特异性，这应使临床医生保持谨慎的乐观态度。
