Rigolet M H, Lubetzki C, Penet C, Iba-Zizen M T, Derdelacou K, Lyon-Caen O, Lhermitte F, Chain F
Clinique de Neurologie et de Neuropsychologie, Hôpital de la Salpêtrière, Paris.
Rev Neurol (Paris). 1989;145(5):378-83.
Monocular stimulation of each visual hemifield can show an interhemispheric asymmetry of VEP. Validity of this test needs a reproducibility of responses and exclusion of stimulation induced by eye movements. In a prospective study of 22 MS cases, it appeared that interhemispheric asymmetry was a criterion of dissemination is space and had a good diagnostic value: MS became clinically definite in 10/12 cases; in 10 other cases in which a correlative MRI-VEP study was possible, there were disseminated high signal areas in T2 weighted sequences on hemispheric MRI. In 7/10 cases, these areas were located on retrochiasmatic visual pathways. With MRI, VEP are the most performant tests for early diagnosis in MS. Technical progress will improve its fiability. Prospective correlative clinical, electrophysiological and MRI studies are necessary on a larger number of MS patients.
对每个视觉半视野进行单眼刺激可显示视觉诱发电位（VEP）的半球间不对称性。该测试的有效性需要反应的可重复性以及排除眼球运动引起的刺激。在一项对22例多发性硬化症（MS）病例的前瞻性研究中，发现半球间不对称是空间播散的一个标准，具有良好的诊断价值：12例中有10例临床确诊为MS；在另外10例可行相关MRI-VEP研究的病例中，半球MRI的T2加权序列中有散在的高信号区。在10例中的7例中，这些区域位于视交叉后视觉通路。对于MS的早期诊断，MRI和VEP是最有效的检查方法。技术进步将提高其可靠性。有必要对更多的MS患者进行前瞻性的临床、电生理和MRI相关研究。
