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[妊娠与肾上腺功能不全。关于一例病例及管理程序的提示]

[Pregnancy and adrenal insufficiency. Apropos of a case and reminder of management procedures].

作者信息

Tschupp M J, Laurent M C, Le Pors-Lemoine P, Roze J M, Hespel J P

机构信息

Service de Gynécologie-Obstétrique, Hôpital Sud, Rennes.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1988;17(2):216-9.

PMID:3385157
Abstract

The authors report a case of pregnancy which proceeded normally in a patient who had Addison's disease. This is not a common condition for obstetricians to meet. Thanks to replacement hormone therapy a patient with Addison's disease can become fertile and pregnancy usually starts in a patient whose chronic adrenal insufficiency (Addison's disease) is known and has been treated. The consequences of this association are reviewed: In the first trimester of pregnancy the hormone state may become more disturbed because of intestinal troubles and can become acutely decompensated because of the "stress" of delivery and its immediate consequences. There are no maternal or fetal repercussions so long as hormone replacement is adequate. The delivery can be by the vaginal route unless there are obstetric contra-indications. These are the particular precautions that have to be undertaken, together with regular supervision of the mother to maintain her hormonal equilibrium: Looking for, prevention and treatment of any condition that may lead to adrenal decompensation: these are particularly intestinal upsets in the first trimester and urinary tract infections. At the end of pregnancy the patient should be hospitalised with resuscitation carried out during and after delivery. These may need to be performed in addition to any surgical procedure that is carried out. The infant does not have any particular treatment and can breast-feed.

摘要

作者报告了一例艾迪生病患者正常妊娠的病例。这对产科医生来说并非常见情况。得益于激素替代疗法,艾迪生病患者可以受孕,妊娠通常始于已知患有慢性肾上腺功能不全(艾迪生病)且已接受治疗的患者。本文回顾了这种关联的后果:在妊娠早期,激素状态可能因肠道问题而变得更加紊乱,并可能因分娩“应激”及其直接后果而急性失代偿。只要激素替代充足,就不会对母体或胎儿产生影响。除非有产科禁忌证,否则可经阴道分娩。这些是必须采取的特殊预防措施,同时要对母亲进行定期监测以维持其激素平衡:寻找、预防和治疗任何可能导致肾上腺失代偿的情况:这些情况在妊娠早期尤其为肠道不适和尿路感染。妊娠末期患者应住院,并在分娩期间及之后进行复苏。除了进行任何外科手术外,可能还需要进行这些操作。婴儿无需特殊治疗,可以进行母乳喂养。

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