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一种罕见的脑干炎症综合征——Clippers,是神话还是事实?病例报告及批判性综述。

A RARE BRAINSTEM INFLAMMATORY SYNDROME, CLIPPERS, MYTH OR FACT. CASE REPORT WITH CRITICAL REVIEW.

机构信息

CЕNTЕR OF INFECTIOUS DISORDERS OF THE NERVOUS SYSTEM, SI "L.V. GROMASHEVSKY INSTITUTE OF EPIDEMIOLOGY AND INFECTION DISEASESOF NAMS OF UKRAINE", KYIV, UKRAINE.

SUMY STATE UNIVERSITY, SUMY, UKRAINE.

出版信息

Wiad Lek. 2021;74(1):161-164.

PMID:33851608
Abstract

A very rare inflammatory disease of CNS, CLIPPERS syndrome, was recently described and only a few sporadic cases are reported in the medical literature. Its etiology and pathogenesis are unknown, that together with the polymorphic and sometimes confounding neurological manifestations, and radiological findings represent a real diagnostic and therapeutic challenge for clinicians. Aim: To highlight the importance of clear and specific diagnostic assessment. Here we present the case of a 40-year-old male with a subacute lymphocytic midbrain inflammation accompanied by vasculitis. We discuss the symptoms, imaging and treatment of this lesion.

摘要

一种非常罕见的中枢神经系统炎症性疾病,即 CLIPPERS 综合征,最近被描述,在医学文献中仅报道了少数散发病例。其病因和发病机制尚不清楚,加上多形性和有时令人困惑的神经表现和放射学发现,这对临床医生来说是一个真正的诊断和治疗挑战。目的:强调明确和具体的诊断评估的重要性。在这里,我们介绍了一例 40 岁男性亚急性淋巴细胞性中脑炎症伴血管炎的病例。我们讨论了该病变的症状、影像学和治疗。

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1
A RARE BRAINSTEM INFLAMMATORY SYNDROME, CLIPPERS, MYTH OR FACT. CASE REPORT WITH CRITICAL REVIEW.一种罕见的脑干炎症综合征——Clippers,是神话还是事实?病例报告及批判性综述。
Wiad Lek. 2021;74(1):161-164.
2
CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders.CLIPPERS:伴有脑桥血管周围强化的慢性淋巴细胞性炎症,对类固醇治疗有反应。对炎症性中枢神经系统疾病范围内一种日益被认识的病症的综述。
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World Neurosurg. 2015 Dec;84(6):2077.e1-3. doi: 10.1016/j.wneu.2015.07.057. Epub 2015 Aug 4.
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[Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) associated with swelling in the brainstem: a case report].[慢性淋巴细胞性炎症伴桥脑周围血管强化且对类固醇有反应(CLIPPERS)并伴有脑干肿胀:一例报告]
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Atypical chronic lymphocytic inflammation with pontocerebellar perivascular enhancement responsive to steroids (CLIPPERS), primary angiitis of the CNS mimicking CLIPPERS or overlap syndrome? A case report.类固醇反应性脑桥小脑角血管周围强化伴非典型慢性淋巴细胞炎症(CLIPPERS)、原发性中枢神经系统血管炎模拟 CLIPPERS 或重叠综合征?一例报告。
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Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) With Extrapontine and Pulmonary Involvement: Case Report of a Rare Presentation and Review of Literature.类固醇反应性脑桥边缘带淋巴细胞血管周炎伴慢性淋巴细胞炎症(CLIPPERS)伴脑外和肺部受累:一种罕见表现的病例报告及文献复习。
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