Krishnan V P, Golwala Zainab, Kanvinde Purva, Patel Swati, Rao Sudha, Mudaliar Sangeeta
Department of PediatricHaemato-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
Department of Neonatology, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
Indian J Pathol Microbiol. 2021 Apr-Jun;64(2):347-350. doi: 10.4103/IJPM.IJPM_501_20.
Immature platelet fraction (IPF) is a quantification of immature platelets in the circulation reflecting the state of thrombopoiesis in the marrow. Normal reference range for IPF has been established in adults. Reference intervals in neonates are highly dependent on gestational age of the neonate. Complete blood counts (CBC) with IPF of all neonates admitted in neonatal intensive care unit (NICU) were analyzed using Mindray BC-6800 Auto Hematology analyzer. Platelet count of less than 150 × 10^9/L was assigned as thrombocytopenia. Neonates were divided into four groups as per the corrected gestational age (CGA) on the day of CBC analysis: 28-32 weeks, 32-34 weeks, 34-37 weeks, and >37 weeks according to World Health Organization (WHO) classification. Mean, standard deviation, and 95% confidence interval for IPF was calculated in each group and reference range for IPF was derived. Mean IPF in neonates with normal platelet count was term--3.58 (95% CI 3.29 to 3.87), late preterm Neonates (34-37 weeks)--4.14 (95% CI 3.82 to 5.0), moderate preterm neonates (32-34 weeks)--4.14 (95% CI 3.46 to 4.82), and in Very Preterm neonates (28-32 weeks)--IPF of 5.51 (95% CI 3.95 to 7.07). We aimed to establish a reference range for IPF in neonates of different gestational age groups. The IPF values in neonates were comparable between hematology analyzers in neonates with normal platelet counts.
未成熟血小板分数（IPF）是对循环中未成熟血小板的定量，反映了骨髓中的血小板生成状态。已确定成人IPF的正常参考范围。新生儿的参考区间高度依赖于新生儿的胎龄。使用迈瑞BC-6800全自动血液分析仪对新生儿重症监护病房（NICU）收治的所有新生儿进行全血细胞计数（CBC）并检测IPF。血小板计数低于150×10^9/L被定义为血小板减少症。根据CBC分析当天的校正胎龄（CGA），将新生儿分为四组：按照世界卫生组织（WHO）的分类，分别为28 - 32周、32 - 34周、34 - 37周和>37周。计算每组IPF的均值、标准差和95%置信区间，并得出IPF的参考范围。血小板计数正常的新生儿中，足月儿的平均IPF为3.58（95%CI 3.29至3.87），晚期早产儿（34 - 37周）为4.14（95%CI 3.82至5.0），中度早产儿（32 - 34周）为4.14（95%CI 3.46至4.82），极早产儿（28 - 32周）的IPF为5.51（95%CI 3.95至7.07）。我们旨在建立不同胎龄组新生儿IPF的参考范围。血小板计数正常的新生儿中，不同血液分析仪检测的IPF值具有可比性。
