MacQueen B C, Christensen R D, Henry E, Romrell A M, Pysher T J, Bennett S T, Sola-Visner M C
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Women and Newborn's Clinical Program, Intermountain Healthcare, Salt Lake City, UT, USA.
J Perinatol. 2017 Jul;37(7):834-838. doi: 10.1038/jp.2017.48. Epub 2017 Apr 6.
The immature platelet fraction (IPF) is a laboratory measurement analogous to the reticulocyte count, but reflecting the thrombopoietic state. Similar to a reticulocyte count, it can be expressed as a percent (IPF%=percent of platelets that are immature) or as an absolute number per μl blood; the immature platelet count (IPC=IPF% × platelets per μl of blood).
Using a retrospective analysis of de-identified data from non-thrombocytopenic neonates, we created reference intervals for IPF% and IPC. We then tested the value of these measurements for categorizing thrombocytopenic neonates.
New charts display reference intervals for IPF% and IPC on the day of birth according to gestational age, and during the first 90 days after birth. Neonates with hyporegenerative varieties of thrombocytopenias (syndromes, small for gestational age, birth asphyxia) had lower IPF% and IPC than did neonates with consumptive thrombocytopenias (immune-mediated, infection, disseminated intravascular coagulation, necrotizing enterocolitis; both P<0.0001).
The new reference interval charts can be used to recognize abnormal IPFs. The IPF parameters can help clarify the kinetic mechanism responsible for thrombocytopenias in neonates.
未成熟血小板分数（IPF）是一种类似于网织红细胞计数的实验室检测指标，但反映的是血小板生成状态。与网织红细胞计数类似，它可以表示为百分比（IPF% = 未成熟血小板的百分比）或每微升血液中的绝对数量；未成熟血小板计数（IPC = IPF%×每微升血液中的血小板数）。
通过对非血小板减少症新生儿的去识别数据进行回顾性分析，我们创建了IPF%和IPC的参考区间。然后我们测试了这些检测指标对血小板减少症新生儿进行分类的价值。
新图表显示了根据胎龄在出生当天以及出生后前90天的IPF%和IPC的参考区间。再生低下型血小板减少症（综合征、小于胎龄儿、出生窒息）的新生儿的IPF%和IPC低于消耗性血小板减少症（免疫介导、感染、弥散性血管内凝血、坏死性小肠结肠炎）的新生儿（两者P<0.0001）。
新的参考区间图表可用于识别异常的IPF。IPF参数有助于阐明新生儿血小板减少症的动力学机制。
