Molineux D, Steptoe A
Department of Psychology, St George's Hospital Medical School, University of London, UK.
J Hypertens. 1988 May;6(5):361-5.
Twenty-four adolescent boys with a positive and 40 boys with a negative parental history of hypertension (PH+ and PH-, respectively) were studied at rest and during exercise on a bicycle ergometer at work loads ranging from 25 to 150 W. Each group was divided into fit and unfit categories on the basis of oxygen consumption at a heart rate (HR) of 150 beats/min. Blood pressure (BP) at rest averaged 114.2/68.8 mmHg in the PH+ group and 110.9/70.3 mmHg in the PH- group. Age and body weight did not differ between subgroups, although resting HR was lower in fit than in unfit subjects (P less than 0.01). Oxygen consumption increased with exercise but did not differ between groups at any work level. However, systolic BP was significantly higher in the PH+ group than in the PH- group at both 100 W (163.1 +/- 12.3 versus 156.7 +/- 12.2 mmHg) and 150 W (174.3 +/- 12.5 versus 166.6 +/- 10.4 mmHg, P less than 0.05). These results suggest that the exaggerated BP responses to exercise, characteristic of hypertensive patients, may be present in normotensive adolescents with an increased risk of developing the disorder, and may reflect pathophysiological changes that precede sustained BP elevation.
对24名有高血压家族史阳性的青春期男孩和40名有高血压家族史阴性的男孩（分别为PH+和PH-）进行了研究，研究内容包括静息状态以及在自行车测力计上进行运动时的情况，运动负荷范围为25至150瓦。根据心率为150次/分钟时的耗氧量，将每组分为健康组和非健康组。PH+组静息血压平均为114.2/68.8 mmHg，PH-组为110.9/70.3 mmHg。各亚组之间年龄和体重无差异，尽管健康受试者的静息心率低于非健康受试者（P<0.01）。耗氧量随运动增加，但在任何工作水平下两组之间均无差异。然而，在100瓦（163.1±12.3对156.7±12.2 mmHg）和150瓦（174.3±12.5对166.6±10.4 mmHg，P<0.05）时，PH+组的收缩压均显著高于PH-组。这些结果表明，高血压患者特有的对运动的血压反应过度，可能存在于患高血压风险增加的血压正常的青少年中，并且可能反映了持续血压升高之前的病理生理变化。
