J Drugs Dermatol. 2021 Apr 1;20(4):s10-s16. doi: 10.36849/JDD.2021.589b.
The skin barrier is a multifaceted microenvironment, comprised not only of structural and molecular components that maintain its integrity, but also a lipid matrix comprising an equimolar ratio of cholesterol, free fatty acids, and ceramides. Lipid abnormalities induced by environmental or pathological stimuli are often associated with impaired skin barrier function and integrity. Incorporation of skin lipids in skincare formulations to help fortify barrier function has become widespread. While there are resources available to study the barrier, a comprehensive evaluation of skin models, from in situ to in vivo, that focus on alterations of the lipid content, seems to be lacking. This article reviews current methods to evaluate the skin lipid barrier and touches upon the significance of using such models within the cosmetic field to study formulations that incorporate barrier lipids. J Drugs Dermatol. 20(4 Suppl):s10-16. doi:10.36849/JDD.S589B.
皮肤屏障是一个多方面的微环境，不仅由维持其完整性的结构和分子组成部分组成，还由一个等摩尔比例的胆固醇、游离脂肪酸和神经酰胺组成的脂质基质组成。环境或病理刺激引起的脂质异常通常与皮肤屏障功能和完整性受损有关。将皮肤脂质纳入护肤品配方中以帮助增强屏障功能已变得广泛。虽然有研究屏障的资源，但似乎缺乏对从原位到体内的皮肤模型的全面评估，这些模型侧重于脂质含量的改变。本文综述了目前评估皮肤脂质屏障的方法，并探讨了在化妆品领域使用这些模型来研究包含屏障脂质的制剂的重要性。J 皮肤病药物杂志。20(4 增刊):s10-16。doi:10.36849/JDD.S589B。
