J Drugs Dermatol. 2021 Apr 1;20(4):s29-s35. doi: 10.36849/JDD.2021.589E.
The human skin, particularly the stratum corneum, serves as a protective barrier against exogenous factors, including ultraviolet radiation (UVR) and pathogen invasions. The impact of UVR on skin cancer and photoaging has been extensively studied. However, the direct impact of UVR on skin barrier integrity under clinical settings remains poorly explored. Due to their benefits in reducing inflammation and promoting skin barrier repair, ceramide-containing formulations can provide added photoprotection benefits. In this study, the efficacy of a ceramide-containing sunscreen and moisturizer were evaluated in preventing UV-induced skin surface barrier changes. Expert grading, instrumental, and tape-stripping assessments demonstrated that UVR induced erythema and hyperpigmentation and caused changes in skin cells surface morphological organization and maturation. Treatment with a ceramide-containing sunscreen and moisturizing cream routine reduced erythema and hyperpigmentation, improved skin hydration, and maintained normal superficial skin cells morphology and turnover after UVR. Our results indicate that barrier-enforcing lipids formulations can provide additional benefits in patient’s daily routine by strengthening the barrier and improving skin health overall against chronic sun exposure. J Drugs Dermatol. 20(4 Suppl):s29-35. doi:10.36849/JDD.S589E.
人体皮肤，特别是角质层，是抵御外在因素的保护屏障，包括紫外线辐射（UVR）和病原体入侵。UVR 对皮肤癌和光老化的影响已经得到了广泛的研究。然而，在临床环境下，UVR 对皮肤屏障完整性的直接影响仍未得到充分探索。由于含神经酰胺的配方具有减轻炎症和促进皮肤屏障修复的作用，因此可以提供额外的光保护益处。在这项研究中，评估了含有神经酰胺的防晒霜和保湿霜在预防 UVR 诱导的皮肤表面屏障变化方面的功效。专家评分、仪器和胶带剥离评估表明，UVR 引起红斑和色素沉着，并导致皮肤细胞表面形态组织和成熟的变化。使用含有神经酰胺的防晒霜和保湿霜常规治疗可减少红斑和色素沉着，改善皮肤水分，并在 UVR 后维持正常的浅表皮肤细胞形态和更新。我们的结果表明，强化屏障的脂质配方可以为患者的日常生活提供额外的益处，通过增强屏障和改善整体皮肤健康来预防慢性阳光暴露。J 皮肤病药物杂志。20(4 增刊):s29-35. doi:10.36849/JDD.S589E.
