Roemer R B, Forsyth K, Oleson J R, Clegg S T, Sim D A
Aerospace and Mechanical Engineering Department, University of Arizona, Tucson 85724.
Int J Hyperthermia. 1988 Jul-Aug;4(4):401-15. doi: 10.3109/02656738809016493.
Experiments were performed to determine the dose-related effects of the intravenous administration of a vasodilator (hydralazine) on normal muscle blood perfusion during localized hyperthermia. Fourteen anaesthetized outbred canines were investigated, seven receiving the recommended dose level of 0.5 mg/kg and seven receiving one-quarter of that level. The changes in blood perfusion were estimated using two methods: calculation of an effective blood perfusion magnitude and the use of state and parameter estimation techniques. Both methods showed that the changes in blood perfusion induced by the hydralazine were significant, and that the differences between the results for the two drug doses were not significantly different. This suggests that low doses may be useful in humans, giving the same resultant blood perfusion increase but with a decreased patient risk relative to standard therapeutic doses of hydralazine. While the trends in the blood perfusion changes were the same for both calculation methods the effective perfusion method frequently yielded blood perfusion magnitudes significantly different from those obtained using the state and parameter estimation technique. The differences are postulated to be due to the fact that the effective perfusion values include conduction effects, thus overpredicting the amount of perfusion present. Thus, while the effective blood perfusion can be used as a qualitative indication of blood perfusion changes under certain conditions, we do not recommend its use as a quantitative measure of perfusion.
进行实验以确定静脉注射血管扩张剂（肼屈嗪）对局部热疗期间正常肌肉血液灌注的剂量相关影响。对14只麻醉的杂种犬进行了研究，7只接受推荐剂量水平0.5mg/kg，7只接受该剂量水平的四分之一。使用两种方法估计血液灌注的变化：计算有效血液灌注量以及使用状态和参数估计技术。两种方法均显示，肼屈嗪引起的血液灌注变化显著，且两种药物剂量的结果之间差异无统计学意义。这表明低剂量在人类中可能有用，能带来相同的血液灌注增加效果，但相对于肼屈嗪的标准治疗剂量，患者风险降低。虽然两种计算方法的血液灌注变化趋势相同，但有效灌注方法得出的血液灌注量常常与使用状态和参数估计技术获得的结果显著不同。据推测，差异是由于有效灌注值包括传导效应，因此高估了实际存在的灌注量。因此，虽然有效血液灌注在某些情况下可用作血液灌注变化的定性指标，但我们不建议将其用作灌注的定量测量方法。
