Molecular Pathogenesis Program, the Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY 10016, USA; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA.
Immunity. 2021 Apr 13;54(4):614-616. doi: 10.1016/j.immuni.2021.03.015.
Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1TRAIL astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination.
肠道天然杀伤细胞诱导的微生物组干扰素信号传递对于最小化大脑和脊髓外周炎症反应至关重要。在最近一期的《自然》杂志上，Sanmarco、Wheeler 等人定义了干扰素信号如何诱导 LAMP1TRAIL 星形胶质细胞，后者导致炎症性 T 细胞死亡，从而减轻脱髓鞘小鼠模型中的退化。
