Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; International PhD Program (IPP) of the Institute for Molecular Medicine (IMB) Mainz, Mainz, Germany.
Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany; Focus Program Translational Neuroscience (FTN) Mainz, Mainz, Germany; Research Center for Immunotherapy (FZI) Mainz, Mainz, Germany.
Neuron. 2021 May 5;109(9):1423-1425. doi: 10.1016/j.neuron.2021.04.009.
In a recent issue of Nature, Sanmarco et al. reveal a novel mechanism by which astrocytes maintain an anti-inflammatory state in the central nervous system (CNS). IFNγ released by gut-licensed meningeal NK cells was found to induce TRAIL expression on astrocytes, causing effector T cell apoptosis.
在最近一期的《自然》杂志上，Sanmarco 等人揭示了星形胶质细胞在中枢神经系统 (CNS) 中维持抗炎状态的一种新机制。研究发现，肠道授权脑膜 NK 细胞释放的 IFNγ 诱导星形胶质细胞表达 TRAIL，导致效应 T 细胞凋亡。
