巴西南部两例神经管缺陷病例与妊娠早期使用度鲁特韦有关。
Two cases of neural tube defects with dolutegravir use at conception in south Brazil.
机构信息
Federal University of Health Sciences of Porto Alegre, School of Medicine, Porto Alegre, RS, Brazil; Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre, RS, Brazil.
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
出版信息
Braz J Infect Dis. 2021 Mar-Apr;25(2):101572. doi: 10.1016/j.bjid.2021.101572. Epub 2021 Apr 11.
Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.
多替拉韦（DTG）是全球应用最广泛的抗逆转录病毒药物之一，在大多数 HIV 治疗指南中被推荐作为一线治疗方案。尽管其使用频率较低，但在非洲博茨瓦纳，它的使用与神经管缺陷（NTD）的发生风险增加相关。在此，我们描述了巴西阿雷格里港市的两名女性在接受 DTG 治疗期间怀孕并发生 NTD 的病例。
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