脑深部电刺激的自我调整会延迟帕金森病的优化。
Self-adjustment of deep brain stimulation delays optimization in Parkinson's disease.
机构信息
Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain.
出版信息
Brain Stimul. 2021 May-Jun;14(3):676-681. doi: 10.1016/j.brs.2021.04.001. Epub 2021 Apr 11.
BACKGROUND
Parkinson's Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery.
OBJECTIVE
To assess whether the use of the advanced functions of a patient's programmer would facilitate programming of deep brain stimulation.
METHODS
Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings.
RESULTS
The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055).
CONCLUSIONS
The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.
背景
帕金森病患者在接受脑深部电刺激手术后需要进行耗时的编程，以优化刺激参数。
目的
评估患者程控器的高级功能的使用是否有助于脑深部电刺激的程控。
方法
在这项单中心、前瞻性、随机、对照研究中，将 30 名患者随机分配到使用患者程控器的高级模式或简单模式。主要结局是优化刺激设置所需的天数。
结果
简单模式下优化刺激所需的天数明显减少（88.5 ± 33.1 天 vs. 142.1 ± 67.4 天，p = 0.01）。此外，高级模式组的副作用发生率更高（5.4 ± 3.1 比 2.6 ± 1.9，p = 0.0055）。
结论
患者程控器高级功能的使用会延迟编程优化，并且与更多的副作用相关。这些发现强调了需要其他更快、更安全的刺激编程方法。
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