Ocular Immunology, Jules Gonin Eye Hospital, Lausanne, Switzerland.
Pediatric Immuno-rheumatology, CHUV, University of Lausanne, Lausanne, Switzerland.
Klin Monbl Augenheilkd. 2021 Apr;238(4):469-473. doi: 10.1055/a-1384-0351. Epub 2021 Apr 14.
To investigate demographics and causes of pediatric uveitis in a Swiss tertiary reference center over a 20-year period.
Retrospective cohort study on patients with uveitis aged less than 16 years seen at Jules-Gonin Eye Hospital between 1 January 2000 and 31 December 2019.
Out of 2846 patients with uveitis seen in the Jules-Gonin Eye Hospital Ocular Immune-Infectiology Department, 317 (11.1%) were under 16 years of age and were included in this study. Median age at onset of the uveitis was 8.9 years (range 0 - 16). Anterior uveitis was the most frequent presentation (45.1%) followed by posterior uveitis in 26.2%, intermediate uveitis in 23.3%, and panuveitis in 5.4%. The inflammation was most frequently bilateral and non-granulomatous. A systemic inflammatory disease was found in 34% of the cases and an infectious cause in 24%.
The repartition of the location of the uveitis was similar to previous reports from Western countries. Uveitis in juvenile idiopathic arthritis is the most frequent etiology related to a systemic disease in children. An infectious cause was found in 24% of our patients, which is a greater proportion than in adult cohorts.
在瑞士一家三级参考中心，调查 20 年来儿科葡萄膜炎的人口统计学和病因。
回顾性队列研究，研究对象为 2000 年 1 月 1 日至 2019 年 12 月 31 日期间在朱勒斯·戈宁眼科医院就诊的年龄小于 16 岁的葡萄膜炎患者。
在朱勒斯·戈宁眼科医院眼科免疫感染科就诊的 2846 例葡萄膜炎患者中，317 例（11.1%）年龄小于 16 岁，纳入本研究。葡萄膜炎发病的中位年龄为 8.9 岁（范围 0-16）。前葡萄膜炎是最常见的表现（45.1%），其次是后葡萄膜炎（26.2%）、中间葡萄膜炎（23.3%）和全葡萄膜炎（5.4%）。炎症最常为双侧且非肉芽肿性。34%的病例发现有系统性炎症性疾病，24%的病例有感染性病因。
葡萄膜炎的部位分布与之前来自西方国家的报告相似。在儿童中，与全身疾病相关的幼年特发性关节炎性葡萄膜炎是最常见的病因。我们的患者中有 24%发现有感染性病因，这一比例高于成人队列。
