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埃及三角洲地区的真菌性角膜炎:流行病学、危险因素及微生物学诊断

Fungal Keratitis in the Egyptian Delta: Epidemiology, Risk Factors, and Microbiological Diagnosis.

作者信息

Sadik Nashwa, Elzeiny Sara Mohamed, Ali Yasmine Emad, Sobeih Doaa

机构信息

Mansoura Ophthalmic Hospital, Ministry of Health, Mansoura, Egypt.

Ministry of Health, Mansoura, Hanoi, Egypt.

出版信息

Ophthalmic Epidemiol. 2022 Apr;29(2):198-205. doi: 10.1080/09286586.2021.1914667. Epub 2021 Apr 15.

Abstract

PURPOSE

The current study evaluates the epidemiological characteristics, risk factors, and microbiological diagnosis of fungal keratitis among patients living in the Egyptian Delta.

METHODS

This is a prospective hospital-based study that included patients who were clinically diagnosed and confirmed by culture test to have fungal keratitis. Patients were examined at baseline and risk factors were identified and collected. Patients were followed over 6 months and the outcomes were documented.

RESULTS

A total of 171 (67%) of 252 microbial keratitis patients was proved fungal by microbial culture test. Rural residence and agricultural activity were reported in 139 (81.3%) and 85 (49.7%) patients, respectively. Patients presented within 1 week from the start of symptoms were 120 (70.2%). A total of 54 (31.6%) patients reported ocular trauma. Forty patients (23.4%) had prior ocular surgery and 43 (25.1%) patients had a history of previous ocular disorders. species was the most common organism found in 120 (70.17%) patients, followed by fungi that were found in 25 (14.6%) patients. The main outcome was corneal opacity in 132 (77.2%) patients following medical treatment.

CONCLUSION

Filamentary fungal predominance in Mansoura is influenced by the rural residence of its population. Therefore, more efforts in spreading awareness about microbial keratitis among villagers are important to reduce blindness caused by corneal opacity in rural areas.

摘要

目的

本研究评估生活在埃及三角洲地区的真菌性角膜炎患者的流行病学特征、危险因素及微生物诊断情况。

方法

这是一项基于医院的前瞻性研究,纳入临床诊断并经培养试验确诊为真菌性角膜炎的患者。在基线时对患者进行检查,识别并收集危险因素。对患者进行6个月的随访,并记录结果。

结果

252例微生物性角膜炎患者中,共有171例(67%)经微生物培养试验证实为真菌性角膜炎。分别有139例(81.3%)和85例(49.7%)患者报告居住在农村及从事农业活动。症状出现后1周内就诊的患者有120例(70.2%)。共有54例(31.6%)患者报告有眼外伤史。40例(23.4%)患者曾接受过眼部手术,43例(25.1%)患者有既往眼部疾病史。 是在120例(70.17%)患者中发现的最常见病原体,其次是在25例(14.6%)患者中发现的 真菌。主要结局是132例(77.2%)患者经治疗后出现角膜混浊。

结论

曼苏拉地区丝状真菌占优势受当地居民农村居住环境的影响。因此,加大在村民中传播微生物性角膜炎相关知识的力度,对于减少农村地区因角膜混浊导致的失明至关重要。

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