Systematic Evaluation of Clinical Efficacy and Platelet Function of Sofren Injection in the Treatment of Angina Pectoris.

To systematically evaluate the efficacy and safety of sofren injection combined with conventional Western medicine in the treatment of angina pectoris. Randomized controlled trials (RCTs) on the treatment of angina pectoris with sofren injection combined with Western medicine were collected by searching PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Database, Weipu Database, and China Biomedical Literature Service System (CBM) by computer with the retrieval time from establishment of database to August 2020. After literature screening according to the predetermined inclusion and exclusion criteria, data of eligible studies were extracted, and then, a meta-analysis was conducted with the RevMan 5.3 software. The results of meta-analysis showed that the combination of sofren injection and Western medicine improved the platelet aggregation rate of patients (MD = -5.53, 95% CI (-6.42, -4.64), < 0.00001), PAI-1 (SMD = -2.29, 95% CI (-2.57, -2.01), < 0.00001), TXB2 (MD = -11.91, 95% CI (-14.50, -9.32), < 0.00001), duration of angina attack (MD = -2.01, 95% CI (-3.14, -0.87), =0.0005), ECG symptoms (RR = 1.29, 95% CI (1.20, 1.37), < 0.00001), whole blood viscosity (MD = -1.07, 95% CI (-1.66, -0.48), =0.0004), plasma viscosity (MD = -0.27, 95% CI (-0.35, -0.20), < 0.00001), fibrinogen (MD = -0.67, 95% CI (-0.84, -0.50), < 0.00001), whole blood high shear viscosity (MD = -1.04, 95% CI (-1.30, -0.79), < 0.00001), whole blood low shear viscosity (MD = -2.03, 95% CI (-2.53, -1.53), < 0.00001), CRP (MD = -1.96, 95% CI (-3.01, -0.91), =0.0003), IL-6 (MD = -2.79, 95% CI (-4.02, -1.55), < 0.00001), and TNF- (MD = -17.34, 95% CI (-25.86, -8.81), < 0.00001) and better than the Western medicine group, and there was no statistical significance in the incidence of adverse reactions between the two groups (=0.48). The clinical application of sofren injection combined with conventional Western medicine in the treatment of angina pectoris is clear and safe, so it is recommended for clinical application.