胃底腺黏膜型胃腺癌根除前后的长期观察：一例报告
Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Eradication: a Case Report.
作者信息
Takahashi Keitaro, Ueno Nobuhiro, Sasaki Takahiro, Kobayashi Yu, Sugiyama Yuya, Murakami Yuki, Kunogi Takehito, Ando Katsuyoshi, Kashima Shin, Moriichi Kentaro, Tanabe Hiroki, Kamikokura Yuki, Yuzawa Sayaka, Tanino Mishie, Okumura Toshikatsu, Fujiya Mikihiro
机构信息
Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
Department of Diagnostic Pathology, Asahikawa Medical University Hospital, Asahikawa, Japan.
出版信息
J Gastric Cancer. 2021 Mar;21(1):103-109. doi: 10.5230/jgc.2021.21.e11. Epub 2021 Mar 29.
Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before eradication to 0-IIa+IIc and then 0-I after eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by eradication.
胃底腺黏膜型腺癌（GA - FGM）被提议作为胃底腺型腺癌（GA - FG）的一种新变体。然而，目前GA - FGM的进展速度和恶性程度的影响仍不清楚。在此，我们报告首例经内镜观察超过15年的根除前后的黏膜内GA - FGM病例。病变在使用内镜检测15年后显示肿瘤大小相同，无黏膜下浸润且MIB - 1标记指数较低。内镜形态从根除前的0 - IIa变为根除后的0 - IIa + IIc，然后变为0 - I。这些发现表明，不变的肿瘤大小反映了低级别恶性和缓慢生长，并且内镜形态受根除的影响。
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