Chan Sally Shin Jie, Kaliya-Perumal Arun-Kumar, Yeo Quan You, Oh Jacob Yoong Leong
Division of Spine, Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.
Biomedicine (Taipei). 2020 Mar 28;10(1):45-50. doi: 10.37796/2211-8039.1005. eCollection 2020.
Transverse myelitis is an uncommon but well-defined neurological syndrome. However, a high index of suspicion is needed to diagnose this condition, especially when it occurs in concomitance with preexisting spinal canal stenosis. We report our patient, a 48 year old male, who initially presented to our spine clinic with acute onset unilateral lower limb weakness associated with urinary retention, which was suspected to be cauda equina syndrome due to a prolapsed intervertebral disc. However, initial magnetic resonance (MR) imaging showed only mild spinal canal stenosis from L2-L5 and C3- C6 levels; thus, the possibility of cauda equina syndrome was ruled out. A few days later, patient developed ipsilateral upper limb weakness giving an impression of hemiparesis due to stroke. However, imaging of brain returned normal. There was still a dilemma whether symptoms could be due to cervical myelopathy as there was mild cervical cord compression with early myelomalacia changes, but the findings were subtle to come to a definite conclusion. Subsequently, patient desaturated and required ventilatory support. Repeat MR imaging of the cervical spine revealed T2 hyperintensities spanning multiple levels in the cervical cord which highlighted the possibility of transverse myelitis and the diagnosis was clinched after a CSF analysis. Despite the debilitating effects, patient responded well to corticosteroid therapy and gradually recovered. This case is reported to highlight the diagnostic dilemma and the rapid progression of transverse myelitis that demands timely medical intervention to avoid permanent disabilities.
横贯性脊髓炎是一种罕见但定义明确的神经综合征。然而,诊断这种疾病需要高度的怀疑指数,尤其是当它与先前存在的椎管狭窄同时发生时。我们报告了我们的患者,一名48岁男性,他最初因急性发作的单侧下肢无力伴尿潴留就诊于我们的脊柱诊所,由于椎间盘突出,怀疑为马尾综合征。然而,最初的磁共振(MR)成像仅显示L2-L5和C3-C6水平有轻度椎管狭窄;因此,排除了马尾综合征的可能性。几天后,患者出现同侧上肢无力,给人以中风导致偏瘫的印象。然而,脑部成像结果正常。由于存在轻度颈髓压迫并伴有早期脊髓软化改变,症状是否可能由颈椎病引起仍存在两难境地,但这些发现很细微,无法得出明确结论。随后,患者出现血氧饱和度下降,需要通气支持。颈椎的重复MR成像显示颈髓多个节段T2高信号,这突出了横贯性脊髓炎的可能性,脑脊液分析后确诊。尽管有衰弱影响,但患者对皮质类固醇治疗反应良好并逐渐康复。报告此病例是为了突出诊断上的两难境地以及横贯性脊髓炎的快速进展,这需要及时的医疗干预以避免永久性残疾。