Oyibo Aghogho, Gbadegesin Michael A, Odunola Oyeronke A
Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Toxicol Rep. 2021 Apr 2;8:774-784. doi: 10.1016/j.toxrep.2021.03.035. eCollection 2021.
The inadvertent exposure to arsenic has been associated with diverse diseases such as cancers. is a medicinal plant with antidiabetic and antiproliferative properties. Here, we assessed the ameliorative role of Ethanol Leaf extract of (ELVp) in Sodium Arsenite (SA) - induced toxicity in rats after oral treatment for two weeks as follows: Group 1 (Control, distilled water), Group 2 (Vitamin E, 100 mg/kg), Groups 3 and 4 (ELVp, 100 & 200 mg/kg respectively), Group 5 (SA, 2.5 mg/kg), Group 6 (SA + Vit E) and Group 7 (SA + ELVp (100 mg/kg) and Group 8 (SA + ELVp (200 mg/kg). The results indicated that SA significantly increased liver and kidney function markers and elevated platelet, white blood cell (WBC) count and malondialdehyde levels in rats. Additionally, SA decreased Red Blood Cell (RBC), Hemoglobin (HGB) and Hematocrit (HCT) levels in rats (p < 0.05). Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats. However, ELVp ameliorated SA-induced toxicity in the liver and kidney of rats with respect to these markers. Overall, ELVp has hepatoprotective, nephroprotective and apoptotic properties against sodium arsenite-induced toxicity.
意外接触砷与多种疾病如癌症有关。[植物名称]是一种具有抗糖尿病和抗增殖特性的药用植物。在此，我们评估了[植物名称]乙醇叶提取物（ELVp）在大鼠口服治疗两周后对亚砷酸钠（SA）诱导的毒性的改善作用，具体分组如下：第1组（对照组，蒸馏水），第2组（维生素E，100毫克/千克），第3组和第4组（ELVp，分别为100和200毫克/千克），第5组（SA，2.5毫克/千克），第6组（SA + 维生素E），第7组（SA + ELVp（100毫克/千克））和第8组（SA + ELVp（200毫克/千克））。结果表明，SA显著增加了大鼠的肝功能和肾功能指标，并提高了血小板、白细胞（WBC）计数和丙二醛水平。此外，SA降低了大鼠的红细胞（RBC）、血红蛋白（HGB）和血细胞比容（HCT）水平（p < 0.05）。亚砷酸钠导致大鼠肾脏中BCL - 2蛋白>NF - Kb = p53的轻度表达。然而，就这些指标而言，ELVp改善了SA诱导的大鼠肝脏和肾脏毒性。总体而言，ELVp对亚砷酸钠诱导的毒性具有肝脏保护、肾脏保护和抗凋亡特性。
