傅里叶变换红外光谱法在甘油基药物产品和食品补充剂中二甘醇（DEG）污染物检测中的应用。

FT-IR Spectroscopy for the Detection of Diethylene Glycol (DEG) Contaminant in Glycerin-Based Pharmaceutical Products and Food Supplements.

出版信息

Acta Chim Slov. 2020 Jun;67(2):530-536.

Abstract

Identification and determination of diethylene glycol (DEG) in glycerin-based products was successfully achieved using FT-IR spectroscopy. Studied samples included 0.5% to 20% by mass DEGspiked into cough syrup, two paracetamol syrup formulations, and two food supplements. The characteristic DEGwavenumbers at 881 cm-1 and 1083 cm-1 were used for its quantitative determination in the studied samples. A very good accuracy in determining the DEG fraction was achieved with a mean error% of ±2.02% to ±7.69% upon using the corrected absorbance at 881 cm-1. The corrected absorbance at 1083 cm-1 band was used in the case of paracetamol formulations and resulted in a mean error% ranging from ±2.50% to ±10.28%. The values of limit of detection of the current method ranged from 0.051% to 0.068% DEG for all studied samples.

摘要

利用傅里叶变换红外光谱法（FT-IR spectroscopy）成功地对甘油基产品中的二甘醇（DEG）进行了识别和定量测定。研究的样品包括质量分数为 0.5%至 20%的 DEG 掺杂止咳糖浆、两种对乙酰氨基酚糖浆制剂和两种食品补充剂。研究中使用了特征性的 DEG 波数 881cm-1 和 1083cm-1，用于定量测定研究样品中的 DEG 含量。使用校正后的 881cm-1 处的吸光度，可非常准确地测定 DEG 分数，平均误差%为±2.02%至±7.69%。在对乙酰氨基酚制剂的情况下，使用 1083cm-1 波段的校正吸光度，平均误差%的范围为±2.50%至±10.28%。当前方法的检出限（LOD）值在所有研究样品中的范围为 0.051%至 0.068% DEG。