Division of Rheumatology, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, Italy.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, 90127 Palermo, Italy.
Int J Mol Sci. 2023 Feb 18;24(4):4108. doi: 10.3390/ijms24044108.
Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different clinical domains, as pivotal cells crucial in orchestrating the pro-inflammatory response, both at systemic and tissue levels. It has been suggested they act as key players along multiple stages of disease trajectory fueling type 3 immunity, with a significant impact in the initiation and amplification of inflammation as well as in structural damage occurrence, typical of long-standing disease. The aim of our review is to focus on neutrophils' role within the spectrum of SpA, dissecting their functions and abnormalities in each of the relevant disease domains to understand their rising appeal as potential biomarkers and therapeutic targets.
脊柱关节炎（SpA）包含了肌肉骨骼系统、肠道、皮肤和眼睛的炎症性受累，定义了具有共同发病机制背景的异质性疾病。在 SpA 中固有和适应性免疫紊乱的框架内，中性粒细胞在不同的临床领域中出现，作为在系统和组织水平上协调促炎反应的关键细胞，至关重要。有人认为它们在疾病轨迹的多个阶段发挥关键作用，推动 3 型免疫，对炎症的发生和放大以及长期疾病的结构损伤发生有显著影响。我们的综述旨在关注中性粒细胞在 SpA 谱中的作用，剖析它们在每个相关疾病领域中的功能和异常，以了解它们作为潜在生物标志物和治疗靶点的吸引力日益增加。
