内脏脂肪组织中的 microRNAs 与非酒精性脂肪性肝病的关系。
The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease.
机构信息
Department of Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic.
Department of Physiology, Charles University, Faculty of Medicine in Hradec Králové, Czech Republic.
出版信息
Acta Medica (Hradec Kralove). 2021;64(1):1-7. doi: 10.14712/18059694.2021.1.
Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most important causes of liver disease worldwide leading the foreground cause of liver transplantation. Recently miRNAs, small non-coding molecules were identified as an important player in the negative translational regulation of many protein-coding genes involved in hepatic metabolism. Visceral adipose tissue was found to take part in lipid and glucose metabolism and to release many inflammatory mediators that may contribute to progression of NAFLD from simple steatosis to Non-Alcoholic SteatoHepatitis. Since visceral adipose tissue enlargement and dysregulated levels of miRNAs were observed in patients with NAFLD, the aim of this paper is to reflect the current knowledge of the role of miRNAs released from visceral adipose tissue and NAFLD.
非酒精性脂肪性肝病（NAFLD）是全球最重要的肝病病因之一，也是导致肝移植的首要原因。最近，微小 RNA（miRNA），即小分子非编码分子，被确定为肝脏代谢中许多参与负性翻译调控的蛋白编码基因的重要调控因子。内脏脂肪组织参与脂质和葡萄糖代谢，并释放许多可能导致非酒精性脂肪性肝病从单纯性脂肪变性进展为非酒精性脂肪性肝炎的炎症介质。由于内脏脂肪组织增大和 miRNA 水平失调在 NAFLD 患者中被观察到，因此本文旨在反映内脏脂肪组织和 NAFLD 中释放的 miRNA 的作用的最新知识。
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