Xu Min, Ren Weidong, Xiong Feng, Wang Shuzhen, Zhang Lijuan, Liu Chunxia, Huang Xiaofeng, Lei Yali
Department of Cardiac Ultrasound, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, 82# of Qinglong St. Qingyang District, Chengdu, 610031, Sichuan, China.
Department of Ultrasound, Shengjing Hospital of China Medical University, 36# of Sanhao St. Heping District, Shenyang, 110004, Liaoning, China.
Pediatr Cardiol. 2021 Jun;42(5):1200-1208. doi: 10.1007/s00246-021-02601-5. Epub 2021 Apr 15.
Knowing the normal values of left ventricular (LV) systolic synchronicity in the early neonatal period is very important for understanding myocardial function. This retrospective study analyzed data of 105 newborns who were examined using real-time 3-dimensional echocardiography (RT3DE). The time to the point of minimal regional systolic volume (Tmsv) was measured from volume-time curves in each segment. Standard deviation (SD) and maximal difference (Dif) of Tmsv were calculated from 16 (6 basal/6 mid/4 apical), 12 (6 basal/6 mid), and 6 (basal) LV segments with the corresponding parameters adjusted for the R-R interval. Influences of age, sex, gestational age, birth weight, and heart rate on parameters were explored. Data showed no significant difference among Tmsv-16-SD, Tmsv-12-SD, and Tmsv-6-SD. A strong correlation was found between Tmsv-6-SD and Tmsv-6-Dif (r = 0.83, P < 0.001), Tmsv-12-SD and Tmsv-6-SD (r = 0.77, P < 0.001), and Tmsv-12-Dif and Tmsv-6-Dif (r = 0.76, P < 0.001) and a moderate correlation was found between Tmsv-16-SD and Tmsv-16-Dif (r = 0.66, P < 0.001), Tmsv-6-SD and Tmsv-12-Dif (r = 0.62, P < 0.001), and Tmsv-12-SD and Tmsv-6-Dif (r = 0.61, P < 0.001). Heart rate correlated negatively with Tmsv (r = - 0.03 to - 0.11, P < 0.004-0.000), but had no effect on parameters adjusted for %R-R. Age, sex, gestational age, and birth weight did not affect any of these parameters. Tmsv-Dif and Tmsv-SD measured from 16 segments using RT3DE are useful as possible parameters for evaluating LV systolic synchronicity in normal newborns.
了解新生儿早期左心室（LV）收缩同步性的正常数值对于理解心肌功能非常重要。这项回顾性研究分析了105例使用实时三维超声心动图（RT3DE）检查的新生儿的数据。从每个节段的容积-时间曲线测量达到最小区域收缩容积点的时间（Tmsv）。Tmsv的标准差（SD）和最大差值（Dif）根据16个（6个基底段/6个中间段/4个心尖段）、12个（6个基底段/6个中间段）和6个（基底段）左心室节段计算得出，并针对R-R间期调整相应参数。探讨了年龄、性别、胎龄、出生体重和心率对参数的影响。数据显示Tmsv-16-SD、Tmsv-12-SD和Tmsv-6-SD之间无显著差异。发现Tmsv-6-SD与Tmsv-6-Dif之间存在强相关性（r = 0.83，P < 0.001），Tmsv-12-SD与Tmsv-6-SD之间存在强相关性（r = 0.77，P < 0.001），Tmsv-12-Dif与Tmsv-6-Dif之间存在强相关性（r = 0.76，P < 0.001），Tmsv-16-SD与Tmsv-16-Dif之间存在中度相关性（r = 0.66，P < 0.001），Tmsv-6-SD与Tmsv-12-Dif之间存在中度相关性（r = 0.62，P < 0.001），Tmsv-12-SD与Tmsv-6-Dif之间存在中度相关性（r = 0.61，P < 0.001）。心率与Tmsv呈负相关（r = -0.03至-0.11，P < 0.004 - 0.000），但对%R-R调整后的参数无影响。年龄、性别、胎龄和出生体重均不影响这些参数中的任何一个。使用RT3DE从16个节段测量的Tmsv-Dif和Tmsv-SD可作为评估正常新生儿左心室收缩同步性的可能参数。
