Department of Burns and Plastic Surgery, Tangshan Gongren Hospital, China.
J Wound Care. 2021 Apr 1;30(Sup4):S38-S40. doi: 10.12968/jowc.2021.30.Sup4.S38.
Hard-to-heal wounds are a surgical challenge, and diabetic foot ulcers (DFUs) are one of the most common and severe varieties. Previous studies have shown that autologous fat grafting (AFG) and negative pressure wound therapy (NPWT) have the potential to promote wound healing. This case study describes how these two methods together helped in the healing of a serious DFU.
A 65-year-old female patient had a severe DFU on her right foot, with a 30-year history of disease and renal failure. By the time symptoms were evident, regular dressing changes and antibiotic treatment were inadequate. She received surgical debridement, AFG and NPWT. Finally, as the granulation tissue covered the full wound bed, the wound was closed by split-thickness skin grafting. One month later, the DFU was fully healed with no recurrences.
The application of AFG or components of adipose tissue to treat hard-to-heal wounds has been researched at both the molecular level and in clinic. In this case, we have proved the curative effect of jointly using AFG and NPWT.
难愈性伤口是外科领域的一项挑战，糖尿病足溃疡（DFU）是最常见和最严重的类型之一。既往研究表明，自体脂肪移植（AFG）和负压伤口治疗（NPWT）有促进伤口愈合的潜力。本病例研究描述了这两种方法如何协同作用，帮助治愈一例严重的 DFU。
一名 65 岁女性患者右足部患有严重 DFU，病史 30 年，合并肾衰竭。症状出现时，常规换药和抗生素治疗已不足。患者接受了外科清创术、AFG 和 NPWT。最终，当肉芽组织完全覆盖整个创面床时，采用中厚皮片移植闭合伤口。一个月后，DFU 完全愈合，无复发。
AFG 或脂肪组织成分在分子水平和临床应用上均有研究用于治疗难愈性伤口。在本病例中，我们证明了联合应用 AFG 和 NPWT 的疗效。
