• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

采用脂肪移植预防足部溃疡复发和疼痛的缓解策略:病例系列

Remission Strategies with Fat Grafting to Prevent Recurrence of Pedal Ulcerations and Pain: A Case Series.

作者信息

Kress Gavin Thomas, Swerdlow Mark, Mohan Natasha, Patel Ketan, Shin Laura

机构信息

From Keck School of Medicine of the University of Southern California (USC), Los Angeles, Calif.

Department of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, Calif.

出版信息

Plast Reconstr Surg Glob Open. 2023 Sep 1;11(9):e5232. doi: 10.1097/GOX.0000000000005232. eCollection 2023 Sep.

DOI:10.1097/GOX.0000000000005232
PMID:37662474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10473342/
Abstract

BACKGROUND

Foot deformities and gait abnormalities can result in locally elevated peak pedal pressures or atypical pedal biomechanics. Combined with underlying comorbidities such as neuropathy, stroke, atrophic fat padding and history of ulcerations, this can lead to recurrent ulcerations and pain. Pedal fat grafting (PFG) is a treatment modality that has been shown to reduce peak pressures and accelerate wound healing. This study aimed to investigate the utility of PFG to treat and prevent ulcerations.

METHODS

We retrospectively analyzed medical history, demographics, wound volume at time of procedure, volume of fat injected, surgical outcomes, and presence of new wounds in 15 patients who underwent PFG at Keck Hospital between 2018 and 2023.

RESULTS

Seventeen feet from 15 patients (63 ± 12 years old, body mass index 30.9 ± 3.1) received PFG with an average volume of fat injected of 10.7 mL and procedure time of 84.6 minutes. At the time of PFG, nine wounds were present on nine feet with an average wound volume of 1.6 ± 2.7 cm. Average follow-up was 6.9 months (range 1-36 months), with no complications or recurrent ulcerations since the procedure.

CONCLUSIONS

PFG is a promising treatment option for reducing peak pedal pressure and preventing ulcer recurrence in patients with various conditions. Further study is warranted for long-term follow-up.

摘要

背景

足部畸形和步态异常可导致局部峰值踏板压力升高或非典型踏板生物力学。再加上潜在的合并症,如神经病变、中风、萎缩性脂肪垫和溃疡病史,这可能导致复发性溃疡和疼痛。足部脂肪移植(PFG)是一种已被证明可降低峰值压力并加速伤口愈合的治疗方式。本研究旨在探讨PFG治疗和预防溃疡的效用。

方法

我们回顾性分析了2018年至2023年在凯克医院接受PFG的15例患者的病史、人口统计学、手术时的伤口体积、注射的脂肪体积、手术结果以及新伤口的情况。

结果

15例患者(63±12岁,体重指数30.9±3.1)的17只脚接受了PFG,平均注射脂肪体积为10.7 mL,手术时间为84.6分钟。在进行PFG时,9只脚上有9处伤口,平均伤口体积为1.6±2.7 cm。平均随访6.9个月(范围1 - 36个月),自手术以来无并发症或复发性溃疡。

结论

PFG是一种有前景的治疗选择,可降低各种情况下患者的峰值踏板压力并预防溃疡复发。有必要进行进一步的长期随访研究。

相似文献

1
Remission Strategies with Fat Grafting to Prevent Recurrence of Pedal Ulcerations and Pain: A Case Series.采用脂肪移植预防足部溃疡复发和疼痛的缓解策略:病例系列
Plast Reconstr Surg Glob Open. 2023 Sep 1;11(9):e5232. doi: 10.1097/GOX.0000000000005232. eCollection 2023 Sep.
2
Autologous Fat Grafting for Pedal Fat Pad Atrophy: A Prospective Randomized Clinical Trial.自体脂肪移植治疗足垫脂肪萎缩:一项前瞻性随机临床试验。
Plast Reconstr Surg. 2016 Nov;138(5):1099-1108. doi: 10.1097/PRS.0000000000002667.
3
Calciphylaxis and nonhealing wounds: the role of the vascular surgeon in a multidisciplinary treatment.钙过敏症与难愈合伤口:血管外科医生在多学科治疗中的作用
J Vasc Surg. 2003 Mar;37(3):501-7. doi: 10.1067/mva.2003.70.
4
M.A.I.D.: a prognostic score estimating probability of healing in chronic lower extremity wounds.M.A.I.D.:一种用于估计慢性下肢伤口愈合概率的预后评分。
Ann Surg. 2009 Apr;249(4):677-81. doi: 10.1097/SLA.0b013e31819eda06.
5
The Influence of Fat Grafting on Skin Quality in Cosmetic Foot Grafting: A Randomized, Cross-Over Clinical Trial.脂肪移植对美容足移植中皮肤质量的影响:一项随机、交叉临床试验。
Aesthet Surg J. 2019 Mar 14;39(4):405-412. doi: 10.1093/asj/sjy168.
6
Fat Grafting for Pedal Fat Pad Atrophy in a 2-Year, Prospective, Randomized, Crossover, Single-Center Clinical Trial.脂肪移植治疗足蹼脂肪垫萎缩的 2 年前瞻性随机交叉单中心临床试验
Plast Reconstr Surg. 2018 Dec;142(6):862e-871e. doi: 10.1097/PRS.0000000000005006.
7
Prior Endovascular Intervention Is Not Detrimental to Pedal Bypasses for Ischemic Wounds.既往血管内介入治疗对缺血性伤口的足部旁路手术并无不利影响。
Ann Vasc Surg. 2018 Jul;50:80-87. doi: 10.1016/j.avsg.2017.11.066. Epub 2018 Feb 23.
8
Split Anterior Tibial Tendon Transfer to Dorsal Lateral Foot for Cavovarus Deformities With Neuropathic Ulcerations: A Case Series.经皮前路胫骨肌腱转移至足背外侧治疗伴有神经溃疡的高弓内翻畸形:病例系列研究。
J Foot Ankle Surg. 2022 Jan-Feb;61(1):189-194. doi: 10.1053/j.jfas.2021.08.004. Epub 2021 Aug 15.
9
Heel Wounds Predict Mortality but Not Amputation after Infrapopliteal Revascularization.足跟伤口可预测腘下血管重建术后的死亡率,但不能预测截肢情况。
Ann Vasc Surg. 2018 Aug;51:78-85. doi: 10.1016/j.avsg.2017.11.072. Epub 2018 Mar 6.
10
Volumetric Analysis in Autologous Fat Grafting to the Foot.足部自体脂肪移植的容量分析。
Plast Reconstr Surg. 2019 Sep;144(3):463e-470e. doi: 10.1097/PRS.0000000000005956.

引用本文的文献

1
A Systematic Review of Submetatarsal Fat Pad Augmentation for the Treatment and Prevention of Diabetes-Related Foot Ulceration.跖下脂肪垫增强术治疗及预防糖尿病相关足部溃疡的系统评价
J Foot Ankle Res. 2025 Sep;18(3):e70064. doi: 10.1002/jfa2.70064.
2
Pilot Study: Human Adipose Tissue Allograft for Fat Pad Defects in Patients With Preulcerative Lesions.试点研究:人脂肪组织同种异体移植治疗溃疡性前期病变患者的脂肪垫缺损
Plast Reconstr Surg Glob Open. 2024 Dec 26;12(12):e6404. doi: 10.1097/GOX.0000000000006404. eCollection 2024 Dec.
3
Adipose tissue allograft for the management of a pre-ulcerative plantar lesion in a diabetic neuropathic patient.同种异体脂肪组织移植治疗糖尿病神经病变患者足底溃疡前期病变
Clin Case Rep. 2024 Aug 27;12(9):e9330. doi: 10.1002/ccr3.9330. eCollection 2024 Sep.
4
Adipose-derived stem cells in diabetic foot care: Bridging clinical trials and practical application.脂肪来源干细胞在糖尿病足护理中的应用:连接临床试验与实际应用
World J Diabetes. 2024 Jun 15;15(6):1162-1177. doi: 10.4239/wjd.v15.i6.1162.

本文引用的文献

1
Autologous fat grafting combined with negative pressure wound therapy in severe diabetic foot ulcer: a case study.自体脂肪移植联合负压伤口疗法治疗严重糖尿病足溃疡:病例研究。
J Wound Care. 2021 Apr 1;30(Sup4):S38-S40. doi: 10.12968/jowc.2021.30.Sup4.S38.
2
Patient Selection for Pedal Soft Tissue Augmentation.足部软组织增强的患者选择
Aesthet Surg J Open Forum. 2020 Jun 24;2(3):ojaa031. doi: 10.1093/asjof/ojaa031. eCollection 2020 Sep.
3
A Step in the Right Direction: A Prospective Randomized, Controlled Crossover Trial of Autologous Fat Grafting for Rejuvenation of the Heel.朝着正确方向迈出的一步:自体脂肪移植用于足跟年轻化的前瞻性随机对照交叉试验。
Aesthet Surg J. 2021 Jun 14;41(7):NP959-NP972. doi: 10.1093/asj/sjab095.
4
An overview of Charcot's neuroarthropathy.夏科氏关节病概述。
J Clin Transl Endocrinol. 2020 Oct 28;22:100239. doi: 10.1016/j.jcte.2020.100239. eCollection 2020 Dec.
5
Outcomes and prognosis of diabetic foot ulcers treated by an interdisciplinary team in Canada.加拿大跨学科团队治疗糖尿病足溃疡的结果和预后。
Int Wound J. 2021 Apr;18(2):134-146. doi: 10.1111/iwj.13505. Epub 2020 Nov 25.
6
Fat grafting and platelet-rich plasma for the treatment of diabetic foot ulcers: A feasibility-randomised controlled trial.脂肪移植和富血小板血浆治疗糖尿病足溃疡:一项可行性随机对照试验。
Int Wound J. 2020 Dec;17(6):1578-1594. doi: 10.1111/iwj.13433. Epub 2020 Jul 7.
7
Successful Fat Grafting in a Patient With Thromboangiitis Obliterans.成功的脂肪移植治疗血栓闭塞性脉管炎患者。
Adv Skin Wound Care. 2019 Dec;32(12):1-4. doi: 10.1097/01.ASW.0000604192.77577.6f.
8
AUtologous fat graft in foot calcaneal postsurgical chronic ulcer.自体脂肪移植治疗足部跟骨术后慢性溃疡。
Injury. 2019 Aug;50 Suppl 4:S64-S67. doi: 10.1016/j.injury.2019.08.016. Epub 2019 Aug 16.
9
Volumetric Analysis in Autologous Fat Grafting to the Foot.足部自体脂肪移植的容量分析。
Plast Reconstr Surg. 2019 Sep;144(3):463e-470e. doi: 10.1097/PRS.0000000000005956.
10
Fat Grafting for Pedal Fat Pad Atrophy in a 2-Year, Prospective, Randomized, Crossover, Single-Center Clinical Trial.脂肪移植治疗足蹼脂肪垫萎缩的 2 年前瞻性随机交叉单中心临床试验
Plast Reconstr Surg. 2018 Dec;142(6):862e-871e. doi: 10.1097/PRS.0000000000005006.