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不同的收入援助方案对药物使用和药物相关危害的影响:一项随机对照试验。

Effect of alternative income assistance schedules on drug use and drug-related harm: a randomised controlled trial.

机构信息

Department of Sociology, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre on Substance Use, Vancouver, BC, Canada.

Department of Sociology, University of British Columbia, Vancouver, BC, Canada; British Columbia Centre on Substance Use, Vancouver, BC, Canada.

出版信息

Lancet Public Health. 2021 May;6(5):e324-e334. doi: 10.1016/S2468-2667(21)00023-2. Epub 2021 Apr 12.

DOI:10.1016/S2468-2667(21)00023-2
PMID:33857455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8176782/
Abstract

BACKGROUND

The synchronised monthly disbursement of income assistance, whereby all recipients are paid on the same day, has been associated with increases in illicit drug use and serious associated harms. This phenomenon is often referred to as the cheque effect. Because payment variability can affect consumption patterns, this study aimed to assess whether these harms could be mitigated through a structural intervention that varied income assistance payment timing and frequency.

METHODS

This randomised, parallel group trial was done in Vancouver, Canada, and enrolled recipients of income assistance whose drug use increased around payment days. The recipients were randomly assigned 1:2:2 to a control group that received monthly synchronised income assistance payments on government payment days, a staggered group in which participants received single desynchronised monthly income assistance payments, or a split and staggered group in which participants received desynchronised income assistance payments split into two instalments per month, 2 weeks apart, for six monthly payment cycles. Desynchronised payments in the intervention groups were made on individual payment days outside the week of the standard government schedules. Randomisation was through a pre-established stratified block procedure. Investigators and statisticians were masked to group allocation, but participants and front-line staff were not. Complete final results are reported after scheduled interim analyses and the resulting early stoppage of recruitment. Under intention-to-treat specifications, generalised linear mixed models were used to analyse the primary outcome, which was escalations in drug use, predefined as a 40% increase in at least one of: use frequency; use quantity; or number of substances used during the 3 days after government payments. Secondary analyses examined analogous drug use outcomes coinciding with individual payments as well as exposure to violence. This trial is registered with ClinicalTrials.gov, NCT02457949.

FINDINGS

Between Oct 27, 2015, and Jan 2, 2019, 45 participants were enrolled to the control group, 72 to the staggered group, and 77 to the split and staggered group. Intention-to-treat analyses showed a significantly reduced likelihood of increased drug use coinciding with government payment days, relative to the control group, in the staggered (adjusted odds ratio 0·38, 95% CI 0·20-0·74; p=0·0044) and split and staggered (0·44, 0·23-0·83; p=0·012) groups. Findings were consistent in the secondary analyses of drug use coinciding with individual payment days (staggered group 0·50, 0·27-0·96, p=0·036; split and staggered group 0·49, 0·26-0·94, p=0·030). However, secondary outcome analyses of exposure to violence showed increased harm in the staggered group compared with the control group (2·71, 1·06-6·91, p=0·037). Additionally, 51 individuals had a severe or life-threatening adverse event and there were six deaths, none of which was directly attributed to study participation.

INTERPRETATION

Complex results indicate the potential for modified income assistance payment schedules to mitigate escalations in drug use, provided measures to address unintended harms are also undertaken. Additional research is needed to clarify whether desynchronised schedules produce other unanticipated consequences and if additional measures could mitigate these harms.

FUNDING

Canadian Institutes of Health Research, Providence Health Care Research Institute, Peter Wall Institute for Advanced Research, Michael Smith Foundation for Health Research.

摘要

背景

同步发放月度收入援助金,所有受助者在同一天领取,这与非法药物使用和严重相关危害的增加有关。这种现象通常被称为支票效应。由于支付的可变性会影响消费模式,因此本研究旨在评估通过改变收入援助支付时间和频率的结构性干预措施是否可以减轻这些危害。

方法

本随机、平行组试验在加拿大温哥华进行,招募了那些在发薪日左右吸毒量增加的收入援助受助人。受助者随机分为对照组(每月同步领取政府发薪日的收入援助金)、错开组(参与者每月领取一次非同步的单独收入援助金)或拆分错开组(参与者每月领取两次非同步的收入援助金,间隔两周,共六个付款周期)。干预组的非同步付款在政府标准时间表之外的个别付款日进行。随机分配通过预先确定的分层块程序进行。调查人员和统计人员对分组分配情况不知情,但参与者和一线工作人员知情。在预定的中期分析后报告完整的最终结果,并导致提前停止招募。根据意向治疗规范,使用广义线性混合模型分析主要结局,即药物使用增加,定义为至少以下一项增加 40%:使用频率;使用量;或在政府付款后 3 天内使用的物质数量。次要分析检查了与个别付款同时发生的类似药物使用结果以及暴露于暴力的情况。本试验在 ClinicalTrials.gov 注册,编号为 NCT02457949。

结果

2015 年 10 月 27 日至 2019 年 1 月 2 日期间,对照组有 45 名参与者,错开组有 72 名,拆分错开组有 77 名。意向治疗分析显示,与对照组相比,错开组(调整后的优势比 0.38,95%CI 0.20-0.74;p=0.0044)和拆分错开组(0.44,0.23-0.83;p=0.012)的政府发薪日药物使用增加的可能性显著降低。次要分析显示,与个别付款日药物使用情况一致(错开组 0.50,0.27-0.96,p=0.036;拆分错开组 0.49,0.26-0.94,p=0.030)。然而,暴力暴露的次要结局分析显示,错开组与对照组相比,伤害增加(2.71,1.06-6.91,p=0.037)。此外,51 人发生严重或危及生命的不良事件,6 人死亡,均与研究参与无关。

结论

复杂的结果表明,修改收入援助金支付时间表有可能减轻药物使用的增加,但也需要采取措施解决意外的伤害。需要进一步研究以明确非同步时间表是否会产生其他意外后果,以及是否可以采取其他措施减轻这些伤害。

资金

加拿大卫生研究院、普罗维登斯医疗保健研究所以及迈克尔·史密斯基金会健康研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/8176782/8cddb69954ae/nihms-1698677-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/8176782/bba878d2c0c5/nihms-1698677-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/8176782/8cddb69954ae/nihms-1698677-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/8176782/bba878d2c0c5/nihms-1698677-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7545/8176782/8cddb69954ae/nihms-1698677-f0002.jpg

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