产前血清锰水平与 4 岁时的神经发育。
Prenatal manganese serum levels and neurodevelopment at 4 years of age.
机构信息
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Paseo Doctor Begiristain s/n, 20014, San Sebastian, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, C/Monforte de Lemos 3-5, 28029, Madrid, Spain; Department of Preventive Medicine and Public Health, Faculty of Medicine, University of the Basque Country (UPV/EHU), 48940, Leioa, Spain; Department of Social Psychology and Methodology of Behavioral Sciences, Faculty of Psychology, University of the Basque Country (UPV/EHU), Avenida Tolosa 70, 20018, San Sebastian, Spain.
Biodonostia Health Research Institute, Group of Environmental Epidemiology and Child Development, Paseo Doctor Begiristain s/n, 20014, San Sebastian, Spain.
出版信息
Environ Res. 2021 Jun;197:111172. doi: 10.1016/j.envres.2021.111172. Epub 2021 Apr 12.
BACKGROUND
The excess of manganese (Mn) causes severe deleterious effects in the central nervous system, and the developing brain is especially sensitive to Mn overload. However, results of prospective studies regarding Mn neurodevelopmental effects remain inconclusive. The present study aims at studying the association of prenatal Mn exposure and neurodevelopment at 4-5 years of age.
METHODS
Mn serum concentration was measured in 1465 pregnant women from the INMA (INfancia y MedioAmbiente, Environment and Childhood) Project. Neurodevelopment was assessed using a standardized version of the McCarthy Scales of Children's Abilities (MSCA). Multivariate regression models were used for data analysis.
RESULTS
No association was found between Mn levels in serum and any of the McCarthy scales. However, the stratification by sex showed a positive and beneficial association of prenatal Mn levels and the verbal, quantitative and general-cognitive scales in girls (β (95%CI): 4 (0.03, 7.96), 4.5 (0.43, 8.57) and 4.32 (0.6, 8.05), respectively).
CONCLUSIONS
A beneficial association was found for the first time between prenatal Mn levels measured in serum and neurodevelopment of female offspring at 4 years of age, which could have implications on public health policies, specifically on the establishment of policies promoting prenatal health related to dietary deficits of micronutrients such as Mn.
背景
过量的锰（Mn）会对中枢神经系统造成严重的有害影响，而发育中的大脑对 Mn 过载尤其敏感。然而，关于 Mn 对神经发育影响的前瞻性研究结果仍不确定。本研究旨在研究产前 Mn 暴露与 4-5 岁时神经发育的关系。
方法
在 INMA（环境与儿童）项目中，对 1465 名孕妇的血清 Mn 浓度进行了测量。使用 McCarthy 儿童能力量表（MSCA）的标准化版本评估神经发育。采用多变量回归模型进行数据分析。
结果
血清中 Mn 水平与任何 McCarthy 量表均无相关性。然而，按性别分层显示，产前 Mn 水平与女孩的言语、定量和一般认知量表呈正相关和有益关联（β（95%CI）：4（0.03，7.96）、4.5（0.43，8.57）和 4.32（0.6，8.05））。
结论
首次发现血清中产前 Mn 水平与 4 岁女性后代的神经发育呈有益关联，这可能对公共卫生政策产生影响，特别是在制定促进与产前健康相关的政策方面，特别是与饮食中缺乏 Mn 等微量元素有关的政策。
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