Imaging recollection, familiarity, and novelty in the frontoparietal control and default mode networks and the anterior-posterior medial temporal lobe: An integrated view and meta-analysis.

A network-level model of recollection-based recognition (R), familiarity-based recognition (F), and novelty recognition (N) was constructed, and its validity was evaluated through meta-analyses to produce an integrated view of neuroimaging data. The model predicted the following: (a) the overall magnitude of the frontoparietal control network (FPCN) activity (which supports retrieval and decision effort) is in the order of F > R > N; (b) that of the posterior medial temporal network (MTL) activity (which plays a direct role in retrieval) is in the order of R > N > F; (c) that of the anterior MTL activity (which supports novelty-encoding) is in the order of N > R > F; (d) that of the default mode network (DMN) activity (which supports the subjective experience of remembering) is in the order of R > N > F. The meta-analyses results were consistent with these predictions. Subsystem analysis indicated a functional dissociation between the cingulo-opercular vs. frontoparietal components of the FPCN and between the core vs. medial temporal components of the DMN.