College of Petrochemical Technology, Lanzhou University of Technology, Lanzhou, 730050, China.
Chemistry Department, Nazarbayev University, Astana 010000, Kazakhstan.
J Inorg Biochem. 2021 Jul;220:111456. doi: 10.1016/j.jinorgbio.2021.111456. Epub 2021 Apr 8.
The present study attempted to synthesize carbon quantum dots (CQDs) through Aldol polymerization reaction, wherein acetone was used as the carbon source. A nano composite CQDs/AgS/CS was developed by loading as prepared CQDs and AgS nanoparticles on a chitosan substrate (CS). An in-situation growth of nanocomposites was adopted to study their antibacterial properties. Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative) and methicillin-resistant Staphylococcus aureus were selected as the model bacteria. The CQDs/AgS/CS nanocomposites exhibited excellent inhibition not only against common pathogenic bacteria, but also those well-known drug-resistant bacteria. Moreover, compared to traditional antibiotics, the as prepared nanocomposites in the present work do not likely cause bacterial drug resistance, which make them a potential candidate for a new type of clinically applicable antibiotics.
本研究试图通过 Aldol 聚合反应合成碳量子点(CQDs),其中丙酮用作碳源。通过将制备好的 CQDs 和 AgS 纳米粒子负载在壳聚糖基质(CS)上,开发了纳米复合 CQDs/AgS/CS。采用原位生长的方法研究了纳米复合材料的抗菌性能。选择金黄色葡萄球菌(革兰氏阳性)、大肠杆菌(革兰氏阴性)和耐甲氧西林金黄色葡萄球菌作为模型细菌。CQDs/AgS/CS 纳米复合材料不仅对常见的致病菌,而且对著名的耐药菌都表现出了优异的抑制作用。此外,与传统抗生素相比,本工作中制备的纳米复合材料不太可能引起细菌耐药性,这使它们成为一种新型临床应用抗生素的潜在候选材料。