Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Yongin, Gyeonggi-do, Republic of Korea.
Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul, Republic of Korea.
Atherosclerosis. 2021 May;325:1-7. doi: 10.1016/j.atherosclerosis.2021.01.016. Epub 2021 Jan 31.
Decreased skeletal muscle mass is an important change in body composition with aging. Maintaining the optimal low-density lipoprotein (LDL) cholesterol level is crucial for the prevention of cardiovascular diseases (CVD). We investigated whether muscle mass was associated with dyslipidemia.
We analyzed the data of 17,546 adults from the 2008-2011 Korean National Health and Nutrition Examination Survey (KNHANES) and 5126 adults from the Korean Genome and Epidemiology Study (KoGES). Participants were classified into the lower skeletal muscle mass index (LSMI) group and normal group. LSMI was defined as body mass index (BMI)-adjusted appendicular skeletal muscle mass <0.789 (men) and <0.512 (women) in the KNHANES, and as sex-specific lowest quintile of the BMI-adjusted total skeletal muscle mass in the KoGES. Participants were defined as having dyslipidemia when the serum LDL cholesterol levels were higher than their LDL cholesterol management targets based on their CVD risk level.
The odds ratio with 95% confidence interval (CI) for dyslipidemia of the LSMI group was 1.230 (1.016-1.488, p = 0.034) after adjusting for confounding variables compared to the normal group in the 2008-2011 KNHANES. In the KoGES, the hazard ratio with 95% CI for incident dyslipidemia of the LSMI group compared to the normal group was 1.225 (1.101-1.364, p < 0.001). Regardless of abdominal obesity, LSMI was significantly associated with a higher risk of incident dyslipidemia.
LSMI was associated with dyslipidemia regardless of abdominal obesity. Prevention of muscle mass loss may be an important strategy for LDL cholesterol management.
骨骼肌量减少是人体成分随年龄增长而发生的重要变化。维持最佳的低密度脂蛋白（LDL）胆固醇水平对于预防心血管疾病（CVD）至关重要。我们研究了肌肉量与血脂异常之间的关系。
我们分析了 2008-2011 年韩国国家健康与营养检查调查（KNHANES）的 17546 名成年人和韩国基因组与流行病学研究（KoGES）的 5126 名成年人的数据。参与者被分为低骨骼肌质量指数（LSMI）组和正常组。在 KNHANES 中，LSMI 定义为体质指数（BMI）调整后的四肢骨骼肌质量<0.789（男性）和<0.512（女性），而在 KoGES 中，LSMI 定义为 BMI 调整后的总骨骼肌质量的最低五分位数。当血清 LDL 胆固醇水平高于根据 CVD 风险水平设定的 LDL 胆固醇管理目标时，参与者被定义为患有血脂异常。
在 2008-2011 年 KNHANES 中，与正常组相比，LSMI 组的血脂异常比值比（OR）为 1.230（95%置信区间[CI]：1.016-1.488，p=0.034），调整混杂因素后差异有统计学意义。在 KoGES 中，与正常组相比，LSMI 组发生血脂异常的风险比（HR）为 1.225（95%CI：1.101-1.364，p<0.001）。无论是否存在腹型肥胖，LSMI 与发生血脂异常的风险增加显著相关。
无论是否存在腹型肥胖，LSMI 与血脂异常相关。预防肌肉量减少可能是 LDL 胆固醇管理的重要策略。
