Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea.
Front Endocrinol (Lausanne). 2024 Aug 23;15:1391733. doi: 10.3389/fendo.2024.1391733. eCollection 2024.
Mounting evidence indicates the importance of the interplay between skeletal muscles and lipid metabolism. Remnant cholesterol (remnant-C) is considered one of the principal residual risk factors for cardiovascular disease and metabolic disorders; however, there are limited studies on the impact of remnant-C on sarcopenia.
Data from the Korea National Health and Nutrition Examination Surveys (KNHANES) between 2008 and 2011 were used in this nationwide population-based study. In total, 17,408 participants were enrolled in this study. The subjects were categorized into four groups according to the quartile of remnant-C values. We conducted multivariable logistic regression analysis to evaluate the association between remnant-C and muscle mass measured using dual-energy X-ray absorptiometry.
A total of 1,791 participants (10.3%) presented low muscle mass, and there was a sequential increase in the percentage of low muscle mass across remnant-C quartiles (Q1, 5.2%; Q2, 8.7%; Q3, 11.5%; Q4, 15.7%). In the full adjusted model, those in the highest remnant-C quartile group showed significantly increased odds ratio (OR) for low muscle mass compared with those in the lowest remnant-C group after adjusting for various confounding factors (OR = 1.33, 95% confidence interval (CI) = 1.06-1.68, 0.05). A wide range of subgroups and sensitivity analyses showed consistent results, supporting the robustness of our findings.
Increased remnant-C value was associated with a high risk of low muscle mass in the Korean population. Remnant-C may be a novel marker for the prediction and management of sarcopenia in aging societies.
越来越多的证据表明，骨骼肌肉和脂代谢之间的相互作用非常重要。残余胆固醇（remnant-C）被认为是心血管疾病和代谢紊乱的主要残余风险因素之一；然而，关于残余-C 对肌肉减少症影响的研究有限。
本研究使用了 2008 年至 2011 年韩国国家健康和营养检查调查（KNHANES）的数据。共有 17408 名参与者纳入本项全国性基于人群的研究。根据残余-C 值的四分位数，将受试者分为四组。我们进行了多变量逻辑回归分析，以评估残余-C 与使用双能 X 射线吸收法测量的肌肉量之间的关系。
共有 1791 名参与者（10.3%）存在低肌肉量，随着残余-C 四分位的升高，低肌肉量的百分比呈递增趋势（Q1，5.2%；Q2，8.7%；Q3，11.5%；Q4，15.7%）。在全调整模型中，与残余-C 最低组相比，残余-C 最高四分位组的低肌肉量的比值比（OR）显著增加（OR=1.33，95%置信区间（CI）=1.06-1.68，0.05）。广泛的亚组和敏感性分析均得出了一致的结果，支持了我们研究结果的稳健性。
残余-C 值升高与韩国人群低肌肉量的高风险相关。残余-C 可能是预测和管理老龄化社会肌肉减少症的新标志物。
