Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
J Hazard Mater. 2021 Jun 5;411:125039. doi: 10.1016/j.jhazmat.2021.125039. Epub 2021 Jan 5.
The consumption of pharmaceuticals-contaminated aquatic products could pose risks to human health, and risk assessments considering bioaccessibility can provide better dietary recommendations. In this study, the bioaccessibility of 6 pharmaceuticals (sulfadiazine (SD), sulfapyridine (SPD), roxithromycin (ROX), tylosin (TYL), diclofenac (DIC) and carbamazepine (CMZP)) in several fish species collected from Shanghai markets was evaluated using in vitro simulated digestion. The total mixed pharmaceuticals concentration in freshwater fish were lower than those in marine fish, and statistics showed that the total concentrations of SD, SPD and CMZP in freshwater fish were significantly lower than those of marine fish (p < 0.05). The bioaccessible concentration of each pharmaceutical accounted for 26.3% (TYL) to 101.5% (CMZP) of the total concentration in market fish (n = 70). The bioaccessibility of 6 pharmaceuticals in species of fish was 18.8% (cutlassfish) to 99.6% (bream), which may be related to the physical-chemical properties of the pharmaceutical and the characteristics of the matrix (e.g. lipid content). According to health risk assessments, the consumption of market fish in Shanghai posed no remarkable risk to human health (hazard quotient < 0.099). Ignoring the bioaccessibility of pharmaceuticals in aquatic products might overestimate the human health risks by dietary exposure.
食用受药物污染的水产品可能会对人类健康造成危害，而考虑生物可利用性的风险评估可以提供更好的饮食建议。本研究采用体外模拟消化方法，评估了上海市场采集的几种鱼类中 6 种药物（磺胺嘧啶（SD）、磺胺吡啶（SPD）、罗红霉素（ROX）、泰乐菌素（TYL）、双氯芬酸（DIC）和卡马西平（CMZP））的生物可利用性。淡水鱼中总混合药物浓度低于海水鱼，统计显示淡水鱼中 SD、SPD 和 CMZP 的总浓度明显低于海水鱼（p < 0.05）。市场鱼类中每种药物的可生物利用浓度占总浓度的 26.3%（TYL）至 101.5%（CMZP）（n = 70）。6 种药物在鱼类中的生物可利用性为 18.8%（带鱼）至 99.6%（鲫鱼），这可能与药物的物理化学性质和基质（如脂质含量）的特征有关。根据健康风险评估，上海市场鱼类的食用对人类健康没有显著风险（危害商数 < 0.099）。忽略水产品中药物的生物可利用性可能会通过饮食暴露高估人类健康风险。
