Wang Hong-Sheng, Man Yu-Bon, Wu Fu-Yong, Zhao Yin-Ge, Wong Chris K C, Wong Ming-Hung
Croucher Institute for Environmental Sciences, Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.
J Agric Food Chem. 2010 Nov 10;58(21):11517-24. doi: 10.1021/jf102242m. Epub 2010 Oct 7.
An in vitro gastrointestinal digestion model was used to evaluate bioaccessibility of PAHs in 20 fish species collected from Hong Kong markets. The average bioaccessibilities of PAHs were 24.3 and 31.1%, respectively, in gastric and intestinal conditions. When bioaccessibility was taken into consideration, the values of potency equivalent concentrations (PEC) decreased from 0.53 to 0.18 ng g(-1) for freshwater fish and from 1.43 to 0.35 ng g(-1) for marine fish. This indicated that bioaccessibility should be taken into account for health risk assessment with regard to PAH contamination in fish. The relative accumulation ratios (R(nn)) of PAH congeners were significantly correlated with their physicochemical parameters and their corresponding concentrations reported in subcutaneous fats of Hong Kong residents. The data suggest that R(nn) values calculated in the present study could effectively reflect the accumulations of PAHs in the human body.
采用体外胃肠消化模型评估了从香港市场采集的20种鱼类中多环芳烃的生物可及性。在胃部和肠道条件下，多环芳烃的平均生物可及性分别为24.3%和31.1%。考虑生物可及性后，淡水鱼的等效毒性浓度（PEC）值从0.53 ng g(-1)降至0.18 ng g(-1)，海水鱼从1.43 ng g(-1)降至0.35 ng g(-1)。这表明在评估鱼类中多环芳烃污染对健康的风险时应考虑生物可及性。多环芳烃同系物的相对累积率（R(nn)）与其理化参数以及香港居民皮下脂肪中报告的相应浓度显著相关。数据表明，本研究中计算的R(nn)值可有效反映多环芳烃在人体中的累积情况。
